Catalog Number | Size | Price | Quantity | ||
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BADC-01252 | -- | $-- | Inquiry |
DBCO-SS-aldehyde, a versatile chemical linker utilized in bioconjugation, plays a pivotal role in binding molecules to proteins, peptides, or other biomolecules. Here are four key applications of DBCO-SS-aldehyde:
Antibody-Drug Conjugates: Integral to the synthesis of antibody-drug conjugates (ADCs), DBCO-SS-aldehyde enables the coupling of a drug molecule to an antibody. This strategic linking allows ADCs to selectively target and deliver cytotoxic agents specifically to cancer cells, minimizing harm to healthy cells and enhancing the efficacy of cancer therapy.
Protein Labeling: An essential component in protein labeling, DBCO-SS-aldehyde serves as a crucial tool for attaching fluorescent dyes, biotin, or other detection tags to proteins. This process enables precise visualization, tracking, and quantification of proteins in diverse biological studies, facilitating in-depth exploration of protein interactions, localization, and functions within living cells.
Click Chemistry: Widely employed in “click” chemistry reactions, DBCO-SS-aldehyde stands out for its efficient and selective conjugation capabilities. Its compatibility with azide-functionalized molecules allows for rapid and specific bioconjugation, simplifying the synthesis of intricate biomolecular structures and propelling advancements in drug discovery and molecular diagnostics.
Functional Biomaterials: Leveraging DBCO-SS-aldehyde, researchers can modify and enhance biomaterials for various applications, including tissue engineering and regenerative medicine. By attaching bioactive molecules to scaffold materials, they can boost cell attachment, proliferation, and differentiation, leading to the creation of sophisticated biomaterials that closely mimic natural tissue environments.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.