DBCO-PEG4-SS-TCO

DBCO-PEG4-SS-TCO Catalog number: BADC-01251

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category
ADCs Linker
Product Name
DBCO-PEG4-SS-TCO
Catalog Number
BADC-01251
Molecular Formula
C43H58N4O9S2
Molecular Weight
839.07

Ordering Information

Catalog Number Size Price Quantity
BADC-01251 -- $--
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Canonical SMILES
C1CC=CCCC(C1)OC(=O)NCCSSCCNC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
InChI
InChI=1S/C43H58N4O9S2/c48-40(18-19-42(50)47-34-37-12-7-6-10-35(37)16-17-36-11-8-9-15-39(36)47)44-21-25-53-27-29-55-31-30-54-28-26-52-24-20-41(49)45-22-32-57-58-33-23-46-43(51)56-38-13-4-2-1-3-5-14-38/h1-2,6-12,15,38H,3-5,13-14,18-34H2,(H,44,48)(H,45,49)(H,46,51)/b2-1+/t38-/m1/s1
InChIKey
PLNJLVRXRBJPOE-FXUJNMGCSA-N
Solubility
10 mm in DMSO
Appearance
Light yellow oil
Purity
≥95%
Shelf Life
≥ 2 years
Shipping
Room temperature
Storage
Store at -5°C,keep in dry and avoid sunlight.

DBCO-PEG4-SS-TCO, a versatile bifunctional linker, plays a pivotal role in bioorthogonal chemistry and bioconjugation applications. Here are four key applications of DBCO-PEG4-SS-TCO:

Targeted Drug Delivery: Acting as a bridge between therapeutic agents and targeting molecules like antibodies or ligands, DBCO-PEG4-SS-TCO facilitates precise drug delivery to specific sites in the body. This controlled release mechanism enhances therapeutic efficacy while minimizing off-target effects. Notably, the cleavable disulfide bond within DBCO-PEG4-SS-TCO ensures drug release in the reducing environment of target cells, optimizing treatment outcomes.

Protein Labeling: Exemplifying its utility, DBCO-PEG4-SS-TCO enables site-specific labeling of proteins by conjugating fluorescent dyes or detectable moieties. This strategic attachment empowers researchers to monitor protein localization, interactions, and dynamics in real-time within live cells. Such applications are invaluable for imaging studies and in-depth protein function analyses, shedding light on cellular processes with unprecedented clarity.

Bio-orthogonal Chemistry: Embracing bio-orthogonal reactions, DBCO-PEG4-SS-TCO engages in chemical transformations that harmonize seamlessly with native biochemical pathways. This unique trait renders it indispensable for in vivo investigations necessitating non-disruptive tracking and labeling of biomolecules. Scientists leverage DBCO-PEG4-SS-TCO for precise biomolecule modifications in intricate biological systems, paving the way for groundbreaking discoveries in molecular biology and beyond.

Surface Functionalization: Unveiling a realm of possibilities, DBCO-PEG4-SS-TCO serves as a catalyst for enhancing the biocompatibility and functionality of nanoparticles, polymers, and various biomaterials through surface modifications. These enhancements may include integrating targeting ligands, stealth coatings, or other functional groups that optimize interactions with biological systems. Such tailored modifications are instrumental in crafting cutting-edge materials for diagnostics, therapeutics, and tissue engineering, pushing the boundaries of scientific innovation.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: DBCO-PEG4-SS-TCO
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