DBCO-PEG4-DBCO - CAS 2182601-68-7

DBCO-PEG4-DBCO - CAS 2182601-68-7 Catalog number: BADC-01077

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DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
DBCO-PEG4-DBCO
CAS
2182601-68-7
Catalog Number
BADC-01077
Molecular Formula
C48H50N4O8
Molecular Weight
810.93
DBCO-PEG4-DBCO

Ordering Information

Catalog Number Size Price Quantity
BADC-01077 -- $--
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Description
DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]-3-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]propanamide; N,N'-bis(3-{2-azatricyclo[10.4.0.0,hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-3-oxopropyl)-4,7,10,13-tetraoxahexadecanediamide
IUPAC Name
N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]-3-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]propanamide
Canonical SMILES
C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCNC(=O)CCOCCOCCOCCOCCC(=O)NCCC(=O)N4CC5=CC=CC=C5C#CC6=CC=CC=C64
InChI
InChI=1S/C48H50N4O8/c53-45(49-25-21-47(55)51-35-41-13-3-1-9-37(41)17-19-39-11-5-7-15-43(39)51)23-27-57-29-31-59-33-34-60-32-30-58-28-24-46(54)50-26-22-48(56)52-36-42-14-4-2-10-38(42)18-20-40-12-6-8-16-44(40)52/h1-16H,21-36H2,(H,49,53)(H,50,54)
InChIKey
YCDMQCKYINAWGI-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Purity
>98.0%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Form
Solid

DBCO-PEG4-DBCO, a versatile bifunctional linker, plays a prominent role in bioconjugation chemistry and molecular biology applications. Here are four key applications of DBCO-PEG4-DBCO:

Click Chemistry: Integral to copper-free click chemistry, DBCO-PEG4-DBCO is vital for the strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. This enables precise and efficient conjugation of biomolecules under gentle conditions, making it perfect for labeling sensitive proteins, nucleic acids, and living cells. Consequently, this technique holds significant value for investigating intricate biological systems with minimal interference.

Drug Delivery Systems: The unique bifunctionality of DBCO-PEG4-DBCO positions it as an exceptional linker for constructing drug delivery systems. It facilitates the attachment of therapeutic agents to targeting moieties like antibodies or peptides, ensuring precise delivery to specific cells or tissues. This enhances therapeutic efficacy and diminishes side effects, aligning with the crucial objective of precision medicine.

Polymer and Nanomaterial Functionalization: In the realm of biomaterial modification, DBCO-PEG4-DBCO plays a pivotal role in introducing functional groups or creating biocompatible surfaces on polymers and nanomaterials. By appending bioactive molecules, these materials can be customized for various applications in biosensing, tissue engineering, and diagnostic assays. The linker’s capacity to enable robust and enduring bonding is paramount for the advancement of sophisticated biomaterial innovations.

In Vivo Imaging: Within the domain of in vivo imaging, DBCO-PEG4-DBCO is harnessed for generating fluorescent or radioactive probes that facilitate real-time tracking of biological processes. Through the linkage of imaging agents to specific biomolecules, researchers can visualize and monitor disease progression, cellular interactions, and treatment effects within living organisms. This non-invasive approach aids in comprehensively studying physiological and pathological phenomena in an organismic context.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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