DBCO-PEG4-amine - CAS 1840886-10-3

DBCO-PEG4-amine - CAS 1840886-10-3 Catalog number: BADC-01010

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Category
ADCs Linker
Product Name
DBCO-PEG4-amine
CAS
1840886-10-3
Catalog Number
BADC-01010
Molecular Formula
C29H37N3O6
Molecular Weight
523.62
DBCO-PEG4-amine

Ordering Information

Catalog Number Size Price Quantity
BADC-01010 -- $--
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Synonyms
DBCO-PEG4-amine TFA salt;DBCO-NHCOPEG4-amine
Canonical SMILES
C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCC(=O)NCCOCCOCCOCCOCCN
InChI
InChI=1S/C29H37N3O6/c30-13-15-35-17-19-37-21-22-38-20-18-36-16-14-31-28(33)11-12-29(34)32-23-26-7-2-1-5-24(26)9-10-25-6-3-4-8-27(25)32/h1-8H,11-23,30H2,(H,31,33)
InChIKey
NFJQULPXXATMFO-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Appearance
mPEG6-NH2
Purity
>98.0%
Shelf Life
≥ 2 years
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Form
Liquid

DBCO-PEG4-amine, a versatile chemical linker, plays a pivotal role in bioconjugation and click chemistry applications. Here are four key applications of DBCO-PEG4-amine:

Bioconjugation: Widely embraced in research, DBCO-PEG4-amine serves as a cornerstone for conjugating biomolecules like antibodies, enzymes, and peptides to diverse substrates. By integrating DBCO-PEG4-amine, researchers achieve precise and enduring attachment through strain-promoted azide-alkyne cycloaddition (SPAAC). This approach is indispensable for fabricating targeted therapeutics, diagnostic tools, and functionalized biomaterials with strategic specificity and stability.

Drug Delivery Systems: Within the realm of drug delivery, DBCO-PEG4-amine emerges as a potent modifier for nanoparticles and liposomes, streamlining the incorporation of therapeutic payloads. The PEGylation effect induced by this linker enhances solubility and biocompatibility of drug carriers, consequently bolstering stability and circulation lifespan in the bloodstream. This optimization results in heightened therapeutic efficiency and enhanced drug delivery outcomes.

Diagnostic Imaging: Driving advancements in diagnostic imaging, DBCO-PEG4-amine empowers the customization of cutting-edge imaging agents by enabling the functionalization of imaging probes. This versatility allows for the attachment of fluorescent dyes or radioactive labels to biomolecules, facilitating pinpoint imaging of biological targets. Such precise imaging capabilities contribute significantly to improved disease detection and monitoring practices.

Surface Functionalization: In the domain of biosensors and biomedical devices, DBCO-PEG4-amine plays a pivotal role in surface functionalization strategies. By anchoring onto azide-functionalized surfaces, this linker imparts a robust and bio-inert coating that mitigates nonspecific protein and cell binding. This enhancement elevates the sensitivity, specificity, and biocompatibility of biosensors, as well as medical implants and devices, ensuring optimal performance and efficacy.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Fmoc-Gly3-Val-Cit-PAB | DBCO-PEG4-amine
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