DBCO-PEG3 acetic-EVCit-PAB - CAS 2253947-17-8

DBCO-PEG3 acetic-EVCit-PAB - CAS 2253947-17-8 Catalog number: BADC-01089

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Category
ADCs Linker
Product Name
DBCO-PEG3 acetic-EVCit-PAB
CAS
2253947-17-8
Catalog Number
BADC-01089
Molecular Formula
C54H72N8O13
Molecular Weight
1041.20

Ordering Information

Catalog Number Size Price Quantity
BADC-01089 -- $--
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Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)C(CCC(=O)OC(C)(C)C)NC(=O)COCCOCCOCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
InChI
InChI=1S/C54H72N8O13/c1-36(2)49(52(70)60-42(14-10-26-57-53(55)71)50(68)58-41-20-16-37(34-63)17-21-41)61-51(69)43(22-25-48(67)75-54(3,4)5)59-46(65)35-74-32-31-73-30-29-72-28-27-56-45(64)23-24-47(66)62-33-40-13-7-6-11-38(40)18-19-39-12-8-9-15-44(39)62/h6-9,11-13,15-17,20-21,36,42-43,49,63H,10,14,22-35H2,1-5H3,(H,56,64)(H,58,68)(H,59,65)(H,60,70)(H,61,69)(H3,55,57,71)/t42-,43-,49-/m0/s1
InChIKey
MFLUIFOUUUKGRE-NRVIKBNNSA-N
Solubility
10 mm in DMSO
Purity
≥95%
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.

DBCO-PEG3 acetic-EVCit-PAB is a bifunctional linker molecule used in bioconjugation and biomedical research. Here are some key applications of DBCO-PEG3 acetic-EVCit-PAB:

Targeted Drug Delivery: DBCO-PEG3 acetic-EVCit-PAB can be utilized to link therapeutic drugs to targeting molecules, such as antibodies, for targeted drug delivery. By attaching the drug to an antibody that recognizes specific cancer cells, the therapy can be directed precisely to the tumor site, minimizing off-target effects. This increases the efficacy and reduces the side effects of cancer treatments.

Biomolecular Labeling: This bifunctional linker is valuable in the labeling of biomolecules, such as proteins and nucleic acids, with fluorescent dyes or other probes. The DBCO group enables rapid and stable conjugation through click chemistry, allowing for efficient bioconjugation. This application is essential for imaging studies, flow cytometry, and other diagnostic techniques.

Prodrug Development: In prodrug development, DBCO-PEG3 acetic-EVCit-PAB can be used to create prodrugs that are activated specifically at the disease site. By conjugating the prodrug to a targeting moiety via the DBCO-PEG3 linker, the drug is released only in the target environment. This approach can enhance the therapeutic index and improve the safety profile of potent drugs.

Biocompatible Coatings: DBCO-PEG3 acetic-EVCit-PAB can be incorporated into biocompatible coatings for medical devices and implants. The PEG3 segment provides hydrophilicity and reduces protein adsorption, while the DBCO group allows for easy attachment of bioactive molecules. This makes the devices more compatible with biological tissues and can help in reducing immune response and improving device integration.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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