Desthiobiotin-Iodoacetamide

Desthiobiotin-Iodoacetamide Catalog number: BADC-01861

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Desthiobiotin-Iodoacetamide can be used as an ADC linker.

Category
ADCs Linker
Product Name
Desthiobiotin-Iodoacetamide
Catalog Number
BADC-01861
Molecular Formula
C14H25IN4O3
Molecular Weight
424.28

Ordering Information

Catalog Number Size Price Quantity
BADC-01861 -- $-- Inquiry
Description
Desthiobiotin-Iodoacetamide can be used as an ADC linker.
IUPAC Name
N-[2-[(2-iodoacetyl)amino]ethyl]-6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]hexanamide
Canonical SMILES
CC1C(NC(=O)N1)CCCCCC(=O)NCCNC(=O)CI
InChI
InChI=1S/C14H25IN4O3/c1-10-11(19-14(22)18-10)5-3-2-4-6-12(20)16-7-8-17-13(21)9-15/h10-11H,2-9H2,1H3,(H,16,20)(H,17,21)(H2,18,19,22)/t10-,11+/m0/s1
InChIKey
ASKKBTGJVCEXOA-WDEREUQCSA-N
Appearance
White to Off-white Solid

Desthiobiotin-Iodoacetamide, a versatile chemical reagent in biochemistry and molecular biology, finds diverse applications. Here are four key applications:

Protein Labeling: A cornerstone in protein research, Desthiobiotin-Iodoacetamide is renowned for its selective labeling of cysteine residues within proteins. Through the covalent binding of its iodoacetamide group to cysteine residues, it enables the subsequent identification and extraction of these modified proteins using biotin-streptavidin systems. This methodology is fundamental for delving into protein-protein interactions, post-translational modifications, and the intricate functions of proteins.

Affinity Purification: The incorporation of a biotin moiety elevates Desthiobiotin-Iodoacetamide as a favored tool for affinity purification procedures. Upon labeling proteins, they can be effortlessly purified using streptavidin-coated beads or columns, ensuring a meticulous extraction of the protein of interest from complex mixtures with unparalleled purity and specificity.

Proteomics: Within the realm of proteomics, Desthiobiotin-Iodoacetamide emerges as an indispensable asset for the identification and quantification of cysteine-containing peptides. In mass spectrometry endeavors, it plays a pivotal role in the enrichment and scrutiny of peptides, yielding comprehensive insights into the protein’s architecture and functionality. This aspect is imperative for unraveling the intricacies of the proteome landscape and unearthing novel biomarkers that fuel advancements in biological sciences.

Cell Surface Labeling: An intriguing facet of Desthiobiotin-Iodoacetamide lies in its utility for labeling cell surface proteins, particularly in tracking the dynamics and interactions of membrane proteins through the tagging of cell surface cysteine residues. This application is instrumental in dissecting cell signaling pathways, unraveling receptor-ligand interactions, and deciphering cellular responses to external stimuli, shedding light on the complex interplay within cellular systems.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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