m-PEG8-Ms - CAS 1059588-19-0

m-PEG8-Ms - CAS 1059588-19-0 Catalog number: BADC-00884

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m-PEG8-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
m-PEG8-Ms
CAS
1059588-19-0
Catalog Number
BADC-00884
Molecular Formula
C18H38O11S
Molecular Weight
462.55
Purity
≥95%
m-PEG8-Ms

Ordering Information

Catalog Number Size Price Quantity
BADC-00884 -- $-- Inquiry
Description
m-PEG8-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl methanesulfonate
IUPAC Name
2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl methanesulfonate
Canonical SMILES
COCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)C
InChI
InChI=1S/C18H38O11S/c1-21-3-4-22-5-6-23-7-8-24-9-10-25-11-12-26-13-14-27-15-16-28-17-18-29-30(2,19)20/h3-18H2,1-2H3
InChIKey
AQFJPOUIRSKMIV-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature
Storage
-20°C

m-PEG8-Ms, a polyethylene glycol derivative widely utilized in biochemical and pharmaceutical realms, finds diverse applications.

Drug Delivery Systems: In the realm of drug delivery, m-PEG8-Ms plays a pivotal role in enhancing the solubility and stability of pharmaceuticals. By conjugating polyethylene glycol chains to drug molecules, it elevates their bioavailability and extends their circulation time within the bloodstream.

Protein Conjugation: Within the domain of protein chemistry, m-PEG8-Ms is a cornerstone for pegylation, a process involving the attachment of PEG moieties to proteins. This innovative procedure serves to diminish immunogenicity and prolong the half-life of therapeutic proteins and peptides.

Biocompatible Coatings: Leveraging the hydrophilic properties of PEG, m-PEG8-Ms finds application in forming biocompatible coatings on medical devices and implants. These coatings effectively mitigate protein adsorption and cell adhesion, thereby reducing the risk of immune responses and infections.

Nanoparticle Functionalization: For the functionalization of nanoparticles in diagnostic and therapeutic applications, m-PEG8-Ms emerges as a crucial player. By modifying nanoparticle surfaces with PEG chains, it enhances their stability and biocompatibility in biological settings, leading to the creation of nanoformulations tailored for targeted drug delivery and cutting-edge imaging technologies.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: m-PEG8-Ms
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