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m-PEG5-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00921 | -- | $-- | Inquiry |
m-PEG5-Ms, also known as methoxy polyethylene glycol mesylate, is a reagent commonly used in bioconjugation and polymer modification. Here are some key applications of m-PEG5-Ms:
Protein Modification: m-PEG5-Ms is frequently used to PEGylate proteins, which involves attaching polyethylene glycol (PEG) to enhance their stability and solubility. This modification can reduce immunogenicity and extend the half-life of therapeutic proteins in the bloodstream. As a result, PEGylated proteins often show improved pharmacokinetic properties and therapeutic efficacy.
Drug Delivery Systems: m-PEG5-Ms is utilized in the design of drug delivery vehicles due to its ability to increase the hydrophilicity and biocompatibility of drug carriers. By conjugating PEG to drugs or drug-loaded nanoparticles, researchers can achieve controlled and sustained release profiles. This is particularly valuable for enhancing the targeting and circulation time of therapeutic agents in the body.
Surface Coating: In biomedical device manufacturing, m-PEG5-Ms is employed as a surface coating agent to minimize protein adsorption and cell adhesion. This property is critical for devices like implants and sensors, which require inert surfaces to avoid unwanted biological interactions. PEGylation helps maintain the device’s functionality and reduces fouling in vivo.
Polymer Science: m-PEG5-Ms serves as a key intermediate in the synthesis of various functional polymers with tailored properties. It can be used to introduce mesylate groups into polymer backbones, which then facilitate further chemical modifications or crosslinking reactions. This versatility enables the creation of custom materials for applications ranging from hydrogels to responsive coatings.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
