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Mc-Gly-Gly-Phe-Gly-PAB-OH TFA is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01867 | -- | $-- | Inquiry |
Mc-Gly-Gly-Phe-Gly-PAB-OH TFA, a peptide compound with a combination of glycine, phenylalanine, and p-aminobenzyl alcohol (PAB) residues, is widely utilized in scientific research due to its versatile applications in peptide synthesis and drug development. Its structure, which includes both amino acid sequences and a PAB group, is highly relevant in the design of peptide-based therapeutics, offering potential in a variety of biomedical fields.
One key application of Mc-Gly-Gly-Phe-Gly-PAB-OH TFA is in the realm of peptide drug development, where it serves as an important intermediate in the synthesis of peptide conjugates. The PAB group can be utilized for coupling reactions, enabling the attachment of various therapeutic molecules to the peptide backbone. This ability makes Mc-Gly-Gly-Phe-Gly-PAB-OH TFA a valuable tool for developing targeted drug delivery systems, improving the specificity and efficacy of treatments.
In addition, Mc-Gly-Gly-Phe-Gly-PAB-OH TFA is employed in the study of protein-protein interactions and enzymatic activity. The incorporation of phenylalanine in its sequence allows it to mimic protein structures, aiding in the identification and study of key biological pathways. Researchers can use it to model interactions between peptides and larger biomolecules, facilitating the understanding of molecular mechanisms in cellular processes. This function is particularly crucial in the development of novel inhibitors for various diseases.
Furthermore, Mc-Gly-Gly-Phe-Gly-PAB-OH TFA plays an important role in materials science, particularly in the synthesis of peptide-based materials with desirable properties such as biocompatibility and biodegradability. The incorporation of glycine and phenylalanine residues provides the compound with structural flexibility, while the PAB group enhances its reactivity, making it suitable for the creation of advanced biomaterials. This has applications in the fabrication of scaffolds for tissue engineering and other biomedical devices.
Finally, the use of Mc-Gly-Gly-Phe-Gly-PAB-OH TFA extends to peptide labeling and diagnostics, where it can be modified to attach to various detection molecules. This property is particularly beneficial for molecular imaging, offering insights into the distribution and localization of peptides in vivo. By modifying the compound with fluorescent or radiolabels, researchers can track peptide behaviors in biological systems, assisting in the development of new diagnostic tools and personalized medicine strategies.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
