Inquiry Basket
| Catalog | Product Name | CAS Number |
|---|---|---|
| BADC-01368 | NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT | 2857037-69-3 |
| NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT is a toxin payload in antibody drug conjugates that can inhibit topoisomerase I, and has good ADC activity in vivo and in vitro. | Inquiry | |
| BADC-01369 | Hemiasterlin | 157207-90-4 |
| Hemiasterlin, a highly cytotoxic marine natural product, is used in a targeted therapeutic which was demonstrated by incorporation as a payload in an antibody-drug conjugate (ADC). It acts by inducing mitotic arrest and abnormal spindle formation. | Inquiry | |
| BADC-01370 | Azonafide-PEABA | |
| Azonafide-PEABA is a cytotoxic drug. | Inquiry | |
| BADC-01371 | 2',3'-cGAMP-C2-SH | 2133823-39-7 |
| 2',3'-cGAMP-C2-SH is an ADC Cytotoxin extracted from patent US20210015941. | Inquiry | |
| BADC-01372 | INX-SM-6 | 2734878-16-9 |
| INX-SM-6 is a cytotoxic that can be used for targeted anti-inflammatory agent. INX-SM-6 inhibits human PBMCS producting LPS-induced IL-1β. | Inquiry | |
| BADC-01373 | Corixetan | 1952359-26-0 |
| Corixetan is an efficient chelator with thorium. | Inquiry | |
| BADC-01374 | Hemiasterlin derivative-1 | 1887046-60-7 |
| Hemiasterlin derivative-1 is a derivative of hemiasterlin. Hemiasterlin inhibits cell growth by depolymerizing existing microtubules and inhibiting microtubule assembly. | Inquiry | |
| BADC-01375 | CC-885-CH2-PEG1-NH-CH3 | 2722698-03-3 |
| CC-885-CH2-PEG1-NH-CH3 is a neoDegrader used in Antibody neoDegrader Conjugate (AnDC). | Inquiry | |
| BADC-01376 | INX-SM-56 | 2734878-18-1 |
| INX-SM-56 is an ADC cytotoxin used for the synthesis of anti-VISTA ADC. | Inquiry | |
| BADC-01377 | Pyrrolobenzodiazepine (PBD) | 945490-09-5 |
| Pyrrolobenzodiazepines are a class of natural products with antibiotic or anti-tumor properties. They are produced by various actinomycetes. As a class of DNA-crosslinking agents, pyrrolobenzodiazepines are significantly more potent than systemic chemotherapeutic drugs. | Inquiry | |
| BADC-01378 | S-methyl DM1 | 912569-84-7 |
| S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds tubulin with a Kd of 0.93 μM and inhibits microtubule polymerization. S-methyl DM1 can effectively inhibit microtubule dynamic instability and has anticancer effects. | Inquiry | |
| BADC-01379 | Eribulin | 253128-41-5 |
| Eribulin suppressed centromere dynamics at concentrations that arrest mitosis. At 60 nmol/L eribulin (2 x mitotic IC(50)), the relaxation rate was suppressed 21%, the time spent paused increased 67%, and dynamicity decreased 35% (but without reduction in mean centromere separation), indicating that eribulin decreased normal microtubule-dependent spindle tension at the kinetochores, preventing the signal for mitotic checkpoint passage. [(3)H]eribulin binds soluble tubulin at a single site; however, this binding is complex with an overall K(d) of 46 microM, but also showing a real or apparent very high affinity (K(d) = 0.4 microM) for a subset of 25% of the tubulin. Eribulin also binds microtubules with a maximum stoichiometry of 14.7 +/- 1.3 molecules per microtubule (K(d) = 3.5 microM), strongly suggesting the presence of a relatively high-affinity binding site at microtubule ends. At 100 nM, the concentration that inhibits microtubule plus end growth by 50%, we found that one molecule of eribulin is bound per two microtubules, indicating that the binding of a single eribulin molecule at a microtubule end can potently inhibit its growth. Eribulin does not suppress dynamic instability at microtubule minus ends. Eribulin's in vivo superiority derives from its ability to induce irreversible mitotic blockade, which appears related to persistent drug retention and sustained Bcl-2 phosphorylation. | Inquiry | |
| BADC-01380 | SG2057 | 260417-62-7 |
| SG2057 is a pentyldioxy linked PBD dimer which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts, and also mono-adducts depending on sequence. SG2057 has multilog differential in vitro cytotoxicity against a panel of human tumour cell lines with a mean GI(50) of 212 pM. The agent is highly efficient at producing DNA interstrand cross-links in cells which form rapidly and persist over a 48h period. Cures were obtained in a LOX-IMVI melanoma model following a single administration and dose-dependent activity, including regression responses, observed in SKOV-3 ovarian and HL-60 promyelocytic leukemia models following repeat dose schedules. In the advanced stage LS174T model, SG2057 administered either as a single dose, or in two repeat dose schedules, was superior to irinotecan. SG2057 is therefore a highly active antitumor agent, with more potent in vitro activity and superior in vivo activity to SG2000. | Inquiry | |
| BADC-01381 | Taltobulin hydrochloride | |
| Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic tripeptide cysteine analog, Taltobulin is a potent antimicrotubule that circumvents P-glycoprotein-mediated drug resistance in vitro and in vivo sex. Taltobulin hydrochloride inhibits purified tubulin polymerization, disrupts microtubule organization in cells, and induces mitotic arrest and apoptosis. | Inquiry | |
| BADC-01382 | Fmoc-MMAE | 474645-26-6 |
| Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE) and a potent tubulin inhibitor. | Inquiry | |
| BADC-01383 | Inebilizumab | 1299440-37-1 |
| Inebilizumab is an anti-CD19 monoclonal antibody used to treat adults with neuromyelitis optica spectrum disorders (NMOSD). | Inquiry | |
| BADC-01384 | Aminohexylgeldanamycin hydrochloride | 1146534-45-3 |
| Aminohexylgeldanamycin (AHGDM) hydrochloride, a derivative of Geldanamycin, is a heat shock protein 90 (HSP90) inhibitor. Aminohexylgeldanamycin hydrochloride has anti-angiogenic and anti-tumor activities. | Inquiry | |
| BADC-01385 | DC10SMe | |
| DC10SMe is a DNA alkylating agent useful in the synthesis of antibody drug conjugates (ADCs). DC10SMe has IC50 values of 15 pM, 12 pM and 12 pM against Ramos, Namalwa and HL60/s cancer cells, respectively. | Inquiry | |
| BADC-01386 | PROTAC BRD4 Degrader-9 | 2417370-42-2 |
| PROTAC BRD4 Degrader-9 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. It can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50 values of 0.86 nM and 7.6 nM, respectively. | Inquiry | |
| BADC-01387 | PROTAC BRD4 Degrader-12 | 2417370-90-0 |
| PROTAC BRD4 Degrader-12, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50s of 0.39 and 0.24 nM, respectively. | Inquiry |
