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4-Pentynoyl-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of cryptophycin conjugates.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01764 | -- | $-- |
4-Pentynoyl-Val-Ala-PAB-PNP, a synthetic peptide employed in diverse research and diagnostic contexts, offers a plethora of applications. Here are four key applications showcased with a high degree of perplexity and burstiness:
Protease Activity Assays: In protease activity assays, 4-Pentynoyl-Val-Ala-PAB-PNP serves as a ubiquitous substrate facilitating the measurement of specific protease activity within biological samples. By quantifying the cleavage of this substrate, researchers can delve into the intricate realm of protease function, unraveling potential protease inhibitors crucial for advancing drug discovery endeavors.
Biomarker Development: Redefining biomarker development, the synthetic essence of 4-Pentynoyl-Val-Ala-PAB-PNP renders it an optimal candidate for disease biomarkers linked to protease dysregulation. Its utility in diagnostic tests enables the detection of aberrant protease activity in patient samples, serving as a linchpin for the early detection and monitoring of conditions like cancer and inflammatory diseases.
Drug Screening: Within high-throughput screening platforms, 4-Pentynoyl-Val-Ala-PAB-PNP emerges as a pivotal tool for identifying and assessing potential protease inhibitors. By scrutinizing how candidate compounds interact with this peptide substrate, researchers embark on a quest to unearth effective inhibitors that may spearhead drug development, catalyzing the quest for novel therapeutics.
Enzyme Kinetics Studies: Powering enzyme kinetics studies, 4-Pentynoyl-Val-Ala-PAB-PNP unveils the intricate kinetic properties of proteolytic enzymes. Through a meticulous analysis of substrate cleavage rates, researchers unveil critical parameters like Km and Vmax, crucial for characterizing enzyme behavior and optimizing conditions tailored for industrial and medical applications at the forefront of scientific exploration.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
