Ald-Ph-amido-PEG4-propargyl - CAS 1969299-27-1

Ald-Ph-amido-PEG4-propargyl - CAS 1969299-27-1 Catalog number: BADC-01028

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Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Ald-Ph-amido-PEG4-propargyl
CAS
1969299-27-1
Catalog Number
BADC-01028
Molecular Formula
C19H25NO6
Molecular Weight
363.40
Purity
>98.0%

Ordering Information

Catalog Number Size Price Quantity
BADC-01028 -- $-- Inquiry
Description
Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
C(C#C)OCCOCCOCCOCCNC(C1=CC=C(C=C1)C=O)=O
IUPAC Name
4-formyl-N-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]benzamide
Canonical SMILES
C#CCOCCOCCOCCOCCNC(=O)C1=CC=C(C=C1)C=O
InChI
InChI=1S/C19H25NO6/c1-2-8-23-10-12-25-14-15-26-13-11-24-9-7-20-19(22)18-5-3-17(16-21)4-6-18/h1,3-6,16H,7-15H2,(H,20,22)
InChIKey
LGLOURHNEMIXPE-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
-20°C
Form
Solid

Ald-Ph-amido-PEG4-propargyl, a versatile chemical linker, stands at the forefront of bioconjugation and biomedical research. Explore its wide-ranging applications portrayed with a high degree of perplexity and burstiness:

Drug Delivery Systems: Enter the realm of drug delivery innovation where Ald-Ph-amido-PEG4-propargyl takes center stage. This chemical linker serves as a crucial connector, seamlessly linking therapeutic agents to biocompatible carriers. By facilitating the attachment of drugs to nanoparticles or proteins, it enhances solubility and bioavailability, pushing targeted drug delivery to new heights while minimizing off-target effects.

Bioconjugation Studies: Embark on a journey through the world of bioconjugation where Ald-Ph-amido-PEG4-propargyl emerges as a key player in linking biomolecules to diverse surfaces or molecules. With the propargyl group, precise and long-lasting conjugation is achieved through efficient click chemistry reactions. This application forms the foundation for developing diagnostic assays, therapeutic agents, and biosensors, pushing the boundaries of bioconjugation technology.

PEGylation: Dive into the realm of PEGylation, a technique that transforms molecule stability and solubility, leveraging Ald-Ph-amido-PEG4-propargyl. By attaching polyethylene glycol (PEG) chains to molecules, this compound extends drug half-life and reduces immunogenicity, revolutionizing pharmaceutical formulations. Unleash the power of PEGylation in enhancing the pharmacokinetic profiles of therapeutic proteins and peptides, reshaping the landscape of drug development.

Protein Crosslinking: Embark on a journey of discovery with Ald-Ph-amido-PEG4-propargyl in protein crosslinking studies, unraveling the complex web of protein-protein interactions and structural biology. This chemical linker plays a vital role in creating lasting covalent bonds between proteins, opening doors to exploring intricate molecular assemblies and dynamics. Immerse yourself in the realm of protein function understanding and therapeutic strategy formulation, guided by the insights gleaned from protein crosslinking studies.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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