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Ald-Ph-PEG2-NHS is a non-cleavable 2-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00401 | -- | $-- | Inquiry |
Ald-Ph-PEG2-NHS, a versatile bioconjugation reagent, finds its footing in a diverse spectrum of biomedical and biochemical pursuits. Here are four key applications elaborated with a high level of perplexity and burstiness:
Protein Labeling: A foundational tool in the biologist's arsenal, Ald-Ph-PEG2-NHS assumes a crucial role in the precise labeling of proteins at specific sites. By interacting with primary amines housed within lysine residues, this reagent facilitates the bonding of fluorescent dyes or other molecular reporters. This synergistic alliance allows for exploration into protein localization, interactions, and dynamics through the intricate lens of fluorescence microscopy and other visualization techniques.
Antibody-Drug Conjugates (ADCs): Leading the charge in anticancer breakthroughs, Ald-Ph-PEG2-NHS contributes its expertise to the fusion of cytotoxic drugs with antibodies. This collaboration forges unwavering covalent bonds that orchestrate the targeted delivery of therapeutic payloads to cancerous cells while mitigating collateral damage. Such pinpoint accuracy enhances the efficacy and safety profile of cancer treatments, heralding a new epoch in oncological therapy.
Surface Functionalization: Within the realms of nanotechnology and biomaterials, Ald-Ph-PEG2-NHS plays a pivotal role in customizing surface functionalities. By grafting functional groups onto nanoparticles, beads, or similar materials, it ushers in a realm of opportunities for biomedical applications. This transformation opens doors for attaching biologically active molecules like peptides, antibodies, or ligands, crucial for biosensing, precise drug delivery, and diagnostic assays with finesse and accuracy.
Protein Stabilization: Leading the forefront in protein preservation, Ald-Ph-PEG2-NHS serves as a beacon in enhancing the stability and solubility of proteins. Through the art of pegylation, it shields against aggregation, proteolysis, and immunogenic threats, thereby extending the protein's longevity and bioavailability. This reinforcement proves invaluable in the development of therapeutic interventions and biopharmaceuticals across an array of diseases, embodying the pinnacle of protein preservation science.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
