Ald-Ph-PEG4-bis-PEG3-N3

Ald-Ph-PEG4-bis-PEG3-N3 Catalog number: BADC-01203

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Ald-Ph-PEG4-bis-PEG3-N3 is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Ald-Ph-PEG4-bis-PEG3-N3
Catalog Number
BADC-01203
Molecular Formula
C44H74N10O17
Molecular Weight
1015.12

Ordering Information

Catalog Number Size Price Quantity
BADC-01203 -- $--
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Description
Ald-Ph-PEG4-bis-PEG3-N3 is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Solubility
10 mm in DMSO
Purity
98.0%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature, or blue ice upon request.
Storage
-20°C

Ald-Ph-PEG4-bis-PEG3-N3 is a bifunctional polyethylene glycol (PEG) reagent useful in various biochemical and medical applications. Here are some key applications of Ald-Ph-PEG4-bis-PEG3-N3:

Bioconjugation: Ald-Ph-PEG4-bis-PEG3-N3 is widely used in bioconjugation to link proteins, peptides, or other biomolecules for therapeutic and diagnostic purposes. Its bifunctional nature allows for efficient crosslinking and attachment to different biomolecules. This enhances the stability, solubility, and efficacy of the conjugated molecules in biomedical applications.

Drug Delivery: In drug delivery systems, Ald-Ph-PEG4-bis-PEG3-N3 can be used to modify the surface of nanoparticles or drug carriers. By attaching this reagent, properties such as biocompatibility and circulation time in the bloodstream can be improved. This leads to more effective targeting and controlled release of therapeutic agents.

Surface Modification: Ald-Ph-PEG4-bis-PEG3-N3 is useful for the modification of surfaces in biosensors and medical devices. By coating surfaces with this PEG reagent, nonspecific binding of proteins and cells can be minimized. This results in higher sensitivity and specificity of diagnostic assays and reduces the risk of biofouling in medical implants.

Protein Stabilization: In protein research, Ald-Ph-PEG4-bis-PEG3-N3 is employed to increase the stability and solubility of recombinant proteins. Conjugating proteins with this reagent can prevent aggregation and enhance their functional properties. This is particularly important for the production and storage of therapeutic proteins and enzymes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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