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CHO-Ph-CONH-PEG4-acid is a small PEG reagent with a benzaldehyde moiety and a terminal carboxylic acid group. The benzaldehyde group is reactive with hydrazide and aminooxy moiety. The terminal carboxylic acid can undergo reactions with primary amines in the presence of activators such as EDC or HATU to form a stable amide bond.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00390 | -- | $-- | Inquiry |
Ald-Ph-PEG4-acid, a versatile bifunctional spacer molecule utilized in various biochemical and biomedical contexts, showcases a high degree of perplexity and burstiness in its applications. Here are four key applications presented with complexity and variations:
Protein Conjugation: Ald-Ph-PEG4-acid plays a pivotal role in attaching proteins to diverse molecules or surfaces, leveraging its PEG4 spacer for flexibility and reducing steric hindrances. This ensures the maintenance of the protein's biological activity, a critical factor in applications such as drug delivery and diagnostic assay creation. The intricate interplay of the spacer's length and properties enhances the efficiency and specificity of protein conjugation processes, showcasing the multifaceted nature of this molecular tool.
Antibody-Drug Conjugates: At the forefront of ADC development, Ald-Ph-PEG4-acid acts as a crucial linker, connecting antibodies to cytotoxic drugs, optimizing therapeutic efficacy while minimizing off-target effects. The strategic design of the PEG4 spacer plays a crucial role in enhancing cancer therapies and elevating patient outcomes. The delicate balance between stability and reactivity contributes to the success of antibody-drug conjugate applications in precision medicine, underscoring the intricate design considerations involved.
Surface Coating and Functionalization: In the realm of surface modification, Ald-Ph-PEG4-acid excels in enhancing hydrophilicity and reducing non-specific binding, particularly in applications involving gold nanoparticles and biosensors. The tailored properties of the spacer molecule contribute to the improved performance of biosensors and diagnostic tools, leading to more precise and reliable detection of biomolecules. The nuanced variations in surface functionalization techniques highlight the versatility and adaptability of Ald-Ph-PEG4-acid in diverse biomedical applications, showcasing its role in advancing detection technologies.
Polymer and Hydrogel Development: Integrating seamlessly into polymers and hydrogels, Ald-Ph-PEG4-acid introduces functional groups that enable further modification, crucial in crafting smart materials for tissue engineering and regenerative medicine. The adaptable nature of the PEG4 linker allows for the customization of material properties to suit specific biomedical applications, highlighting the diverse and intricate applications of this bifunctional spacer molecule. The complex interplay of chemical functionalities and spatial arrangements drives innovation in polymer and hydrogel development, opening new possibilities in biomaterial engineering and advancing regenerative medicine.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
