bis-PEG2-endo-BCN - CAS 1476737-97-9

bis-PEG2-endo-BCN - CAS 1476737-97-9 Catalog number: BADC-00955

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Category
ADCs Linker
Product Name
bis-PEG2-endo-BCN
CAS
1476737-97-9
Catalog Number
BADC-00955
Molecular Formula
C28H40N2O6
Molecular Weight
500.63
bis-PEG2-endo-BCN

Ordering Information

Catalog Number Size Price Quantity
BADC-00955 -- $--
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Synonyms
bis(bicyclo[6.1.0]non-4-yn-9-ylmethyl) ((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))dicarbamate
Canonical SMILES
C1CC2C(C2COC(=O)NCCOCCOCCNC(=O)OCC3C4C3CCC#CCC4)CCC#C1
InChI
InChI=1S/C28H40N2O6/c31-27(35-19-25-21-9-5-1-2-6-10-22(21)25)29-13-15-33-17-18-34-16-14-30-28(32)36-20-26-23-11-7-3-4-8-12-24(23)26/h21-26H,5-20H2,(H,29,31)(H,30,32)
InChIKey
NISHVKOYJUQOBR-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Purity
>98.0%
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Form
Solid

Bis-PEG2-endo-BCN, a versatile bifunctional linker, finds extensive utility in bioconjugation and drug delivery realms. Here are four key applications of Bis-PEG2-endo-BCN presented with high perplexity and burstiness:

1. Targeted Drug Delivery: Bis-PEG2-endo-BCN offers a sophisticated means of directing therapeutic agents to precise cells or tissues by binding to biomolecules like antibodies. This targeted strategy minimizes off-target effects, amplifying the therapeutic potency of the drug. Its significance shines in cancer therapy, where accurate delivery to tumor cells holds paramount importance.

2. Diagnostic Imaging: Leveraging Bis-PEG2-endo-BCN, researchers can conjugate imaging agents to targeting ligands, enriching diagnostic imaging practices. This application elevates the contrast and specificity of imaging modalities such as MRI or PET scans, enabling superior visualization and early detection of diseases like cancer and cardiovascular disorders.

3. Protein-Protein Interaction Studies: Bis-PEG2-endo-BCN plays a pivotal role in probing protein-protein interactions, uniting proteins with reporter molecules. This facilitates real-time tracking of complex formation and dissociation, shedding light on protein function and signaling pathways. Unraveling these intricate interactions is indispensable for drug discovery and biochemical investigations.

4. Development of Bioconjugates: Widely embraced in bioconjugate synthesis, Bis-PEG2-endo-BCN fuels the creation of innovative constructs like antibody-drug conjugates (ADCs) and enzyme-prodrug conjugates. By tethering bioactive compounds to carriers or functional molecules, researchers craft novel therapeutics endowed with heightened stability and specificity.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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