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Bis-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bis-PEG9-acid is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00913 | -- | $-- |
Bis-PEG9-acid, a derivative of polyethylene glycol, is widely utilized in biomedical research and bioconjugation. Here are four key applications of Bis-PEG9-acid described with a high degree of perplexity and burstiness:
Drug Delivery Systems: Leveraging the versatility of Bis-PEG9-acid, researchers can modify drug molecules to boost their solubility, stability, and bioavailability. Through the conjugation of drugs with Bis-PEG9-acid, the pharmacokinetic properties of these medications can be enhanced, leading to more potent and efficient treatments. This methodology is particularly beneficial for drugs with low water solubility or rapid clearance rates from the body.
Protein Modification: At the forefront of therapeutic advancements, Bis-PEG9-acid plays a crucial role in protein PEGylation—a process that entails the attachment of polyethylene glycol chains to proteins. This modification elevates the stability and half-life of therapeutic proteins, thereby reducing their immunogenicity and enhancing their therapeutic efficacy. PEGylated proteins find extensive applications in combating various diseases, including cancer and chronic inflammatory conditions.
Surface Coating: Delving into the realm of biocompatibility, Bis-PEG9-acid is harnessed to engineer surfaces for medical devices and implants. By coating surfaces with Bis-PEG9-acid, researchers can curtail protein adsorption and cell adhesion, thereby mitigating the risks of immune reactions and infections. This application is pivotal in elevating the performance and safety standards of implants and other biomedical devices.
Nanotechnology: In the intricate domain of nanotechnology, Bis-PEG9-acid emerges as a cornerstone for functionalizing nanoparticles tailored for targeted drug delivery and imaging endeavors. By attaching Bis-PEG9-acid to the nanoparticle surfaces, researchers can enhance their circulation longevity and targeting precision. This cutting-edge approach bolsters the precision and efficiency of nanoparticle-based therapies and diagnostic tools, ushering in a new era of precision medicine.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
