Bis-PEG7-acid - CAS 94376-75-7

Bis-PEG7-acid - CAS 94376-75-7 Catalog number: BADC-01195

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Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Bis-PEG7-acid
CAS
94376-75-7
Catalog Number
BADC-01195
Molecular Formula
C18H34O11
Molecular Weight
426.46
Bis-PEG7-acid

Ordering Information

Catalog Number Size Price Quantity
BADC-01195 -- $--
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Description
Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid; HOOCCH2CH2O-PEG6-CH2CH2COOH; α,ω-Dipropionic acid hexaethylene glycol; 4,7,10,13,16,19,22-Heptaoxapentacosane-1,25-dioic acid
IUPAC Name
3-[2-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES
C(COCCOCCOCCOCCOCCOCCOCCC(=O)O)C(=O)O
InChI
InChI=1S/C18H34O11/c19-17(20)1-3-23-5-7-25-9-11-27-13-15-29-16-14-28-12-10-26-8-6-24-4-2-18(21)22/h1-16H2,(H,19,20)(H,21,22)
InChIKey
AYUREXAVZVVOJM-UHFFFAOYSA-N
Density
1.186±0.06 g/cm3
Solubility
Soluble in DMSO
LogP
0.05200
PSA
139.21000
Appearance
Pale Yellow or Colorless Oily Matter
Purity
≥95%
Shipping
Room temperature, or blue ice upon request.
Storage
Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Boiling Point
572.8±50.0 °C at 760 mmHg
Form
Solid

Bis-PEG7-acid, a polyethylene glycol-based compound, is commonly utilized in bioconjugation and drug delivery. Here are four key applications of Bis-PEG7-acid presented with heightened perplexity and burstiness:

Drug Delivery: Utilizing Bis-PEG7-acid, researchers engineer biocompatible and hydrophilic drug delivery systems. By conjugating it to drugs or therapeutic agents, it enhances their solubility and stability in the bloodstream, thereby potentially boosting the efficacy and bioavailability of treatments, particularly beneficial for hydrophobic drugs.

Bioconjugation: A versatile tool in bioconjugation, Bis-PEG7-acid facilitates the linkage of biomolecules like proteins, peptides, and antibodies, maintaining their biological activity. This compound enables the creation of multifunctional bioconjugates for both research and therapeutic purposes, showcasing its value in advancing biotechnological applications.

Protein Modification: In the realm of protein modification, Bis-PEG7-acid plays a pivotal role in enhancing the pharmacokinetic properties of proteins. By conjugating polyethylene glycol chains to proteins, it can mitigate immunogenicity and prolong their circulation within the body, a critical aspect in the realm of developing protein-based therapeutics for improved patient outcomes.

Polymer Chemistry: With its unique qualities, Bis-PEG7-acid finds utility in polymer chemistry for crafting copolymers and hydrogels with tailored mechanical and chemical characteristics. These materials hold promise for diverse biomedical applications, including tissue engineering and controlled release systems, illustrating the vast potential of this compound in advancing medical technologies.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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