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Bis-PEG8-acid is a PEG linker containing two terminal carboxylic acid groups. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00907 | -- | $-- |
Bis-PEG8-acid, a versatile bifunctional polyethylene glycol derivative, finds extensive applications in biotechnology and pharmaceutical sectors. Here are four key applications of Bis-PEG8-acid presented with elevated levels of perplexity and burstiness:
Drug Delivery Systems: Central to pharmaceutical advancements, Bis-PEG8-acid plays a pivotal role in crafting sophisticated drug delivery systems. Its inherent hydrophilicity and flexibility contribute to enhancing the solubility and stability of therapeutic agents, ensuring precise delivery to targeted areas. This optimization leads to heightened bioavailability and reduced adverse effects of the medication, offering a paradigm shift in drug administration.
Protein Modification: Delving into the realm of protein engineering, Bis-PEG8-acid emerges as a crucial player in protein modification endeavors. By leveraging this compound, scientists can enhance the stability and solubility of proteins, thus extending the half-life of therapeutic proteins in circulation. This augmentation not only amplifies the efficacy of therapeutic proteins but also mitigates their immunogenicity, elevating their safety profile for clinical applications.
Surface Coating: Employed extensively in the surface coating of medical devices and implants, Bis-PEG8-acid stands as a cornerstone in minimizing biofouling and enhancing biocompatibility. By creating a hydrophilic shield, it prevents the attachment of proteins and cells, consequently reducing the risks of infections and immune reactions. This indispensable application is instrumental in preserving the functionality and durability of medical implants, ensuring optimal performance and patient well-being.
Bioconjugation: In the intricate world of bioconjugation techniques, Bis-PEG8-acid serves as a vital linker molecule, facilitating the attachment of drugs, dyes, or functional molecules to biomolecules like antibodies and peptides. This innovation enables the development of targeted therapies and diagnostic tools by refining the specificity and functionality of bioconjugates. The inclusion of Bis-PEG8-acid guarantees that the conjugated molecules maintain their activity and stability.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
