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Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 is a branched linker that can be used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01664 | -- | $-- |
Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 is a multifunctional polyethylene glycol (PEG) derivative with specific chemical functionalities, making it highly useful in various bioscience applications. Here are some key applications of Amine-PEG3-Lys(PEG3-N3)-PEG3-N3:
Bioconjugation: Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 is utilized in bioconjugation techniques to link biomolecules, such as proteins, antibodies, or DNA, to surfaces or other macromolecules. The amine group reacts with activated carboxyl groups, while the azide groups participate in click chemistry reactions. This enables the creation of stable, functional conjugates with enhanced biological activity or improved pharmacokinetics.
Drug Delivery: This PEGylated compound is used to improve the solubility, stability, and bioavailability of therapeutic agents. By conjugating drugs to Amine-PEG3-Lys(PEG3-N3)-PEG3-N3, it is possible to reduce immunogenicity and enhance circulation time in the bloodstream. This targeted delivery system can help in achieving controlled drug release and minimizing systemic side effects.
Nanoparticle Functionalization: Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 is effective in the surface modification of nanoparticles for biomedical applications. The multivalent nature of PEG allows for the attachment of multiple functional groups, improving the biocompatibility and targeting capabilities of nanoparticles. This is particularly useful for the development of diagnostic imaging agents and precision medicine.
Tissue Engineering: In tissue engineering, Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 is employed to create hydrogels and scaffolds for cell culture and tissue regeneration. The PEGylation offers a hydrophilic environment and reduces protein adsorption, promoting cell viability and growth. These hydrogels can be tailored for specific tissue types, making them vital tools in regenerative medicine.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
