Amino-PEG2-propionic acid - CAS 791028-27-8

Amino-PEG2-propionic acid - CAS 791028-27-8 Catalog number: BADC-01160

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Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Amino-PEG2-propionic acid
CAS
791028-27-8
Catalog Number
BADC-01160
Molecular Formula
C7H15NO4
Molecular Weight
177.20
Amino-PEG2-propionic acid

Ordering Information

Catalog Number Size Price Quantity
BADC-01160 -- $--
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Description
Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
3-(2-(2-Aminoethoxy)ethoxy)propanoic acid; H2N-PEG2-CH2CH2COOH
IUPAC Name
3-[2-(2-aminoethoxy)ethoxy]propanoic acid
Canonical SMILES
C(COCCOCCN)C(=O)O
InChI
InChI=1S/C7H15NO4/c8-2-4-12-6-5-11-3-1-7(9)10/h1-6,8H2,(H,9,10)
InChIKey
DEZXLFKSYRODPB-UHFFFAOYSA-N
Density
1.1±0.1 g/cm3
Solubility
10 mm in DMSO
Flash Point
154.3±23.7 °C
Index Of Refraction
1.467
LogP
-1.21
Vapor Pressure
0.0±1.5 mmHg at 25°C
Appearance
White/off-white solid or liquid (may vary)
Purity
>99.3%
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Boiling Point
331.5±27.0 °C at 760 mmHg

Amino-PEG2-propionic acid is widely utilized in drug delivery systems due to its ability to enhance the solubility and stability of drugs. Its PEG (polyethylene glycol) linker segment allows for increased hydrophilicity, thereby improving the drug’s bioavailability and prolonging its circulation time in the bloodstream. This polymeric component is also flexible and biocompatible, reducing the potential for adverse immune responses. As a result, it facilitates the effective targeting and sustained release of therapeutic agents, making it a crucial component in the design of advanced drug delivery vehicles.

Another significant application of Amino-PEG2-propionic acid lies in bioconjugation, where it serves as a linker molecule for attaching various biomolecules. The amino group allows for covalent bonding with carboxyl groups on proteins, peptides, or other biomolecules, while the PEG chain provides the necessary flexibility and distance to minimize steric hindrance. This is especially valuable in the development of antibody-drug conjugates (ADCs), where the compound enables the attachment of cytotoxic drugs to antibodies, thereby facilitating targeted cancer therapy.

Amino-PEG2-propionic acid also plays a pivotal role in surface modification, particularly for biomedical implants and devices. By grafting this compound onto surfaces, it is possible to enhance the biocompatibility and reduce the nonspecific binding of proteins and cells. This PEGylation technique creates a hydrophilic barrier on the surface, which can significantly improve the performance and longevity of medical implants such as stents, catheters, and prosthetics. This surface modification is crucial for reducing thrombus formation and improving the overall integration of implants within the body.

Finally, in the field of diagnostics, Amino-PEG2-propionic acid is an essential component in the development of sensor technologies. The PEG spacer can be used to strategically position recognition elements such as antibodies or nucleic acids on the surface of biosensors. This spatial arrangement enhances the sensor’s sensitivity and specificity by ensuring optimal interaction with target analytes. Consequently, biosensors incorporating Amino-PEG2-propionic acid linkers are employed in a variety of diagnostic applications, including the detection of pathogens, biomarkers, and environmental contaminants.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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