Amino-PEG8-propionic acid - CAS 756526-04-2

Amino-PEG8-propionic acid - CAS 756526-04-2 Catalog number: BADC-01154

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NH2-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Amino-PEG8-propionic acid
CAS
756526-04-2
Catalog Number
BADC-01154
Molecular Formula
C19H39NO10
Molecular Weight
441.51
Amino-PEG8-propionic acid

Ordering Information

Catalog Number Size Price Quantity
BADC-01154 -- $--
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Description
NH2-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
Amino-PEG8-Acid
IUPAC Name
3-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES
C(COCCOCCOCCOCCOCCOCCOCCOCCN)C(=O)O
InChI
InChI=1S/C19H39NO10/c20-2-4-24-6-8-26-10-12-28-14-16-30-18-17-29-15-13-27-11-9-25-7-5-23-3-1-19(21)22/h1-18,20H2,(H,21,22)
InChIKey
YLKOHZCQTVYVDB-UHFFFAOYSA-N
Density
1.1±0.1 g/cm3
Solubility
10 mm in DMSO
Flash Point
284.7±30.1 °C
Index Of Refraction
1.470
LogP
-3.36
Vapor Pressure
0.0±3.2 mmHg at 25°C
Appearance
White to off-white solid
Purity
> 98.0 %
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Pictograms
Irritant
Signal Word
Warning
Boiling Point
547.1±50.0 °C at 760 mmHg
Form
Solid

Amino-PEG8-propionic acid, a versatile compound with wide-ranging scientific and industrial applications, plays a pivotal role in various key areas. Here are four applications explored with high perplexity and burstiness:

Bioconjugation: A cornerstone of bioconjugation techniques, Amino-PEG8-propionic acid serves as a fundamental link between biomolecules (such as proteins, peptides, or nucleic acids) and surfaces or other molecules. Its PEGylated structure, fostering flexibility and solubility, mitigates steric hindrance and enhances biocompatibility. This feature is crucial for developing precise targeted drug delivery systems and diagnostic tools that promise groundbreaking advancements in personalized medicine.

Material Science: In the realm of material science, Amino-PEG8-propionic acid plays a pivotal role in the surface modification of nanoparticles, polymers, and other materials, boosting their functionality. Leveraging its hydrophilic properties, this compound aids in stabilizing colloidal suspensions and preventing nonspecific binding. Such applications are indispensable for creating cutting-edge materials with tailored properties, especially crucial in the realm of medical devices and nanotechnology, pushing the boundaries of scientific discovery.

Drug Delivery: A key player in drug delivery system design, Amino-PEG8-propionic acid is instrumental in enhancing the solubility and stability of pharmaceutical compounds. Through the conjugation of drugs with PEG chains, the pharmacokinetics and biodistribution of drugs undergo optimization, ultimately elongating the drug's circulation time and diminishing immunogenicity. This transformative approach elevates therapeutic efficacy, paving the way for more efficient and targeted drug delivery mechanisms.

Immunoassays: At the forefront of immunoassay preparation, Amino-PEG8-propionic acid plays a critical role in linking antigens or antibodies to assay surfaces, ensuring precise and sensitive detection of target molecules. PEGylation serves as a crucial tool in minimizing nonspecific interactions, thereby facilitating accurate and sensitive detection. The significance of this application is paramount in the development of diagnostic assays across medical, environmental, and food safety domains, ensuring heightened precision and reliability in various testing scenarios.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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