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NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01152 | -- | $-- |
Amino-PEG2-t-butyl ester, a versatile chemical compound with wide-ranging applications in biochemistry and medicine, is employed in diverse ways. Here are four key applications articulated with a high level of perplexity and burstiness:
Drug Delivery: Serving as a pivotal linker in drug conjugate synthesis, Amino-PEG2-t-butyl ester plays a significant role in enhancing the solubility, stability, and pharmacokinetic properties of therapeutic agents. By tethering drugs to the PEG moiety, formulations can achieve targeted delivery and reduced side effects, revolutionizing the landscape of pharmaceutical development.
Bioconjugation: In the intricate realm of bioconjugation, Amino-PEG2-t-butyl ester emerges as a crucial tool for conjugating biomolecules like antibodies, peptides, and proteins. The flexible PEG linker minimizes steric hindrance, enabling efficient binding and functionalization, thereby empowering the creation of cutting-edge biotechnological instruments and biosensors.
Surface Modification: Amino-PEG2-t-butyl ester finds utility in the modification of nanoparticle surfaces, medical devices, and diagnostic tools. The process of PEGylation helps in reducing non-specific interactions and enhancing biocompatibility, fostering the development of medical implants and diagnostic assays with heightened specificity and minimal immunogenic responses, contributing to advancements in medical technology.
Proteomics: Within the realm of proteomic studies, Amino-PEG2-t-butyl ester proves invaluable for chemically modifying proteins, facilitating purification, labeling, and functional investigations. The selective processing of the ester group reveals free amines for subsequent reactions, enabling detailed exploration of protein-protein interactions, structural biology, and functional proteomics, shedding light on the intricate workings of biological systems.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
