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Amino-PEG8-Boc is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01155 | -- | $-- |
Amino-PEG8-t-butyl ester, a versatile reagent with multifaceted applications in biochemical and biotechnological realms, is highly esteemed for its diverse functionalities. Here are four key applications of Amino-PEG8-t-butyl ester:
Drug Delivery: Delving into the domain of drug delivery systems, Amino-PEG8-t-butyl ester emerges as a pivotal player in enhancing the solubility and stability of pharmaceutical compounds. Through the conjugation of drugs with this PEGylation reagent, researchers embark on a journey to augment the bioavailability and therapeutic efficacy of medicinal agents. This strategy proves particularly efficacious for delivering hydrophobic drugs while mitigating their systemic toxicity.
Protein Conjugation: Within the realm of protein research, Amino-PEG8-t-butyl ester assumes a critical role as a linker, facilitating the attachment of polyethylene glycol (PEG) to proteins, thereby ameliorating their solubility and diminishing immunogenicity. PEGylation, mediated by Amino-PEG8-t-butyl ester, extends the half-life of therapeutic proteins circulating in the bloodstream, heralding a boon in the realm of protein-based drugs and diagnostic reagents.
Surface Modification: Unlocking the potential of surface modification, Amino-PEG8-t-butyl ester emerges as a keystone reagent for altering the surfaces of nanoparticles, biomaterials, and medical devices. By affixing PEG chains to these surfaces, scientists embark on a quest to impede protein adsorption and cellular attachment, thereby mitigating biofouling and elevating biocompatibility levels.
Bioconjugation Chemistry: Embarking on a journey into bioconjugation chemistry, Amino-PEG8-t-butyl ester stands as a crucial linchpin connecting various biomolecules such as antibodies, peptides, and nucleic acids. The PEG spacer integrated through this reagent elevates the stability and functionality of conjugated biopolymers, underscoring its importance in the development of targeted therapeutics, biosensors, and diagnostic assays.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
