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Boc-Aminooxy-PEG2-bromide is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01110 | -- | $-- | Inquiry |
Boc-Aminooxy-PEG2-bromide, a versatile reagent widely utilized in chemical biology and bioconjugation realms, offers a myriad of applications presented with high perplexity and burstiness:
Bioconjugation: Playing a pivotal role in the realm of biomolecular conjugation, Boc-Aminooxy-PEG2-bromide serves as a key player in linking proteins and peptides to diverse compounds. Through its reaction with aldehyde or ketone groups, it forges durable oxime linkages, a crucial step in crafting precise drug delivery systems and cutting-edge biomaterials.
Surface Modification: Embracing versatility, this reagent finds its place in the modification of nanoparticle, biosensor, and medical device surfaces. It enables the immobilization of bioactive entities on varying surfaces, fostering the creation of biocompatible and functionally enhanced interfaces. These tailored surfaces find utility in diagnostic assays, therapeutic devices, and the domain of tissue engineering.
Proteomics: Within the realm of proteomic inquiry, Boc-Aminooxy-PEG2-bromide emerges as a potent tool for labeling and enriching specific proteins. By interacting with carbonyl groups introduced via glycoprotein oxidation, it enables the selective capture and identification of proteins. This methodology aids in unraveling protein modifications, interactions, and the dynamic landscape of the proteome.
Immunoassays: Elevating the sensitivity and precision of immunoassays, Boc-Aminooxy-PEG2-bromide broadens the horizon of conjugation possibilities for antibodies and antigens with reporter molecules. This strategic conjugation enhances signal detection and quantification in assays like ELISA and Western blotting, underscoring its significance in diagnostic scenarios and the domain of biomarker exploration.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
