APN-PEG4-tetrazine

APN-PEG4-tetrazine Catalog number: BADC-01219

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APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
APN-PEG4-tetrazine
Catalog Number
BADC-01219
Molecular Formula
C30H33N7O6
Molecular Weight
587.63

Ordering Information

Catalog Number Size Price Quantity
BADC-01219 -- $--
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Description
APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Solubility
10 mm in DMSO
Purity
≥95%
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.

APN-PEG4-tetrazine is a versatile chemical linker used in bioconjugation and molecular imaging applications. Here are some key applications of APN-PEG4-tetrazine:

Drug Delivery Systems: APN-PEG4-tetrazine enables the precise conjugation of therapeutic agents to target molecules, improving drug delivery efficiency. By attaching drugs to specific biomolecules, this linker helps in directing the drug to the desired location within the body. This targeted delivery can enhance therapeutic efficacy and minimize off-target effects.

Bioconjugation: The use of APN-PEG4-tetrazine in bioconjugation allows for the stable linkage of proteins, peptides, or other biomolecules. This method facilitates the creation of multifunctional biomolecules for various applications. This conjugation technique is widely employed in the development of diagnostics, therapeutics, and biomaterials.

Molecular Imaging: APN-PEG4-tetrazine is utilized in molecular imaging to attach fluorescent dyes or radioactive labels to specific biomolecules. This enables researchers to visualize and track biological processes in real-time. The high specificity and stability of this linker enhance the accuracy and resolution of imaging studies.

Proteomics: In proteomic research, APN-PEG4-tetrazine aids in the study of protein interactions and functions. By conjugating probes to target proteins, scientists can investigate protein networks and their roles in cellular processes. This information is crucial for understanding disease mechanisms and identifying potential therapeutic targets.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: APN-PEG4-tetrazine
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