Azido-PEG3-Val-Cit-PAB-PNP - CAS 2055047-18-0

Azido-PEG3-Val-Cit-PAB-PNP - CAS 2055047-18-0 Catalog number: BADC-01047

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category
ADCs Linker
Product Name
Azido-PEG3-Val-Cit-PAB-PNP
CAS
2055047-18-0
Catalog Number
BADC-01047
Molecular Formula
C34H47N9O12
Molecular Weight
773.79
Azido-PEG3-Val-Cit-PAB-PNP

Ordering Information

Catalog Number Size Price Quantity
BADC-01047 -- $--
Inquiry
Synonyms
4-((14S,17S)-1-azido-14-isopropyl-12,15-dioxo-17-(3-ureidopropyl)-3,6,9-trioxa-13,16-diazaoctadecan-18-amido)benzyl (4-nitrophenyl) carbonate
Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCOCCOCCOCCN=[N+]=[N-]
InChI
InChI=1S/C34H47N9O12/c1-23(2)30(41-29(44)13-16-51-18-20-53-21-19-52-17-15-38-42-36)32(46)40-28(4-3-14-37-33(35)47)31(45)39-25-7-5-24(6-8-25)22-54-34(48)55-27-11-9-26(10-12-27)43(49)50/h5-12,23,28,30H,3-4,13-22H2,1-2H3,(H,39,45)(H,40,46)(H,41,44)(H3,35,37,47)/t28-,30-/m0/s1
InChIKey
HLBCDJANEWKOSX-JDXGNMNLSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Purity
>98.0%
Shelf Life
≥ 2 years
Shipping
Room temperature
Storage
Store at -20 °C, keep in dry and avoid sunlight.
Form
Solid

Azido-PEG3-Val-Cit-PAB-PNP is a linker used in the development of antibody-drug conjugates (ADCs) and other targeted therapeutic systems. Here are some key applications of Azido-PEG3-Val-Cit-PAB-PNP:

Antibody-Drug Conjugates (ADCs): Azido-PEG3-Val-Cit-PAB-PNP is used as a linker to connect cytotoxic drugs to antibodies, allowing for targeted delivery to cancer cells. The valine-citrulline sequence is a cleavable peptide that remains stable in the bloodstream but is degraded by tumor-specific proteases, releasing the drug inside the cancer cells. This helps in minimizing off-target effects and improving the therapeutic index of the drug.

Targeted Drug Delivery: This linker can be employed in the design of targeted drug delivery systems that utilize various targeting ligands, such as peptides or small molecules, to direct therapeutic agents to specific tissues or cells. The azido group allows for versatile bioconjugation techniques, such as click chemistry, facilitating the attachment of a wide range of targeting moieties. This enhances the precision of drug delivery, potentially reducing side effects.

Bioconjugation: In bioconjugation strategies, Azido-PEG3-Val-Cit-PAB-PNP serves as a versatile building block for linking biomolecules, such as proteins, nucleic acids, or nanoparticles. The PEG3 spacer provides flexibility and reduces steric hindrance, improving the conjugation efficiency and the stability of the resulting bioconjugates. This application is valuable in creating diagnostic tools, biosensors, and therapeutics.

Theranostics: Azido-PEG3-Val-Cit-PAB-PNP can be used in the development of theranostic agents, which combine therapeutic and diagnostic functions in a single molecule. By linking imaging agents and therapeutics through this versatile linker, researchers can create compounds that allow for simultaneous disease treatment and monitoring. This dual functionality aids in real-time tracking of therapeutic efficacy and disease progression.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Why Choose BOC Sciences?

Customer Support

Providing excellent 24/7 customer service and support

Project Management

Offering 100% high-quality services at all stages

Quality Assurance

Ensuring the quality and reliability of products or services

Global Delivery

Ensuring timely delivery of products worldwide

Questions & Comments
Verification code
Send Inquiry
Verification code
Inquiry Basket