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Biotin-PEG1-NH2 is a unique biomedical product used in drug delivery and targeted therapy. It consists of biotin, a vitamin essential for enzymatic reactions, coupled to a polyethylene glycol (PEG) spacer and an amino group (NH2). This specific compound enables targeted drug delivery to cells expressing biotin receptors, facilitating treatment for various diseases such as cancer and autoimmune disorders.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01514 | -- | $-- |
Biotin-PEG1-NH2, also known as Biotinylated polyethylene glycol amine, is a bifunctional reagent that can be applied in various biochemical and biotechnological processes. One of its primary applications is in the field of protein and peptide labeling. Due to the strong affinity between biotin and streptavidin or avidin, Biotin-PEG1-NH2 can be used to label proteins and peptides, allowing for their detection and enrichment in complex biological samples. This labeling facilitates efficient workflows in proteomics research, where the identification and quantification of proteins are critical.
Another major application of Biotin-PEG1-NH2 is in drug delivery systems. The PEG (polyethylene glycol) moiety of Biotin-PEG1-NH2 enhances the solubility and biocompatibility of drug conjugates, contributing to improved pharmacokinetics and reduced immune recognition. When coupled with biotin, this molecule can target cells expressing biotin receptors, ensuring more precise delivery of therapeutic agents. Such targeted delivery can enhance the efficacy of treatment while minimizing side effects, making it a valuable tool in developing next-generation pharmaceuticals.
Biotin-PEG1-NH2 is also extensively used in diagnostics, particularly in the development of biosensors and assay platforms. The biotin-streptavidin system is renowned for its high binding affinity and specificity, making Biotin-PEG1-NH2 an excellent candidate for immobilizing biotinylated molecules on sensor surfaces. This application is pivotal in creating highly sensitive and specific assays for diagnostics, which can detect minute concentrations of biomarkers. Consequently, Biotin-PEG1-NH2 plays a crucial role in early disease detection and monitoring.
In addition to the aforementioned applications, Biotin-PEG1-NH2 is instrumental in cell biology research, particularly in the study of cell surface interactions and receptor mapping. By biotinylating cell surface proteins, researchers can use streptavidin-conjugated probes to visualize and track these molecules under various experimental conditions. This technique provides valuable insights into receptor-ligand interactions, cell signaling pathways, and other cellular processes. The use of Biotin-PEG1-NH2, therefore, facilitates advanced research in cellular and molecular biology.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
