Fmoc-Val-Cit-PAB-PNP - CAS 863971-53-3

Fmoc-Val-Cit-PAB-PNP - CAS 863971-53-3 Catalog number: BADC-00369

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Category
ADCs Linker
Product Name
Fmoc-Val-Cit-PAB-PNP
CAS
863971-53-3
Catalog Number
BADC-00369
Molecular Formula
C40H42N6O10
Molecular Weight
766.79
Purity
≥98%
Fmoc-Val-Cit-PAB-PNP

Ordering Information

Catalog Number Size Price Quantity
BADC-00369 100 mg $159 Inquiry
Synonyms
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
InChI
InChI=1S/C40H42N6O10/c1-24(2)35(45-39(50)54-23-33-31-10-5-3-8-29(31)30-9-4-6-11-32(30)33)37(48)44-34(12-7-21-42-38(41)49)36(47)43-26-15-13-25(14-16-26)22-55-40(51)56-28-19-17-27(18-20-28)46(52)53/h3-6,8-11,13-20,24,33-35H,7,12,21-23H2,1-2H3,(H,43,47)(H,44,48)(H,45,50)(H3,41,42,49)/t34-,35-/m0/s1
InChIKey
USMYACISHVPTHK-PXLJZGITSA-N
Sequence
Fmoc-V-Cit-PAB-PNP
Density
1.335±0.06 g/cm3 (Predicted)
Solubility
Soluble in DMSO, water
Melting Point
189°C (dec.)
Appearance
Solid
Shipping
-20°C (International: -20°C)
Storage
Store at -20°C
Pictograms
Irritant
Signal Word
Warning
Boiling Point
1024.0±65.0°C (Predicted)

Fmoc-Val-Cit-PAB-PNP, the prized peptide linker in targeted therapeutic agent synthesis, particularly shines in the realm of antibody-drug conjugates (ADCs).

Antibody-Drug Conjugates (ADCs): Within the realm of cancer therapy, Fmoc-Val-Cit-PAB-PNP plays a pivotal role as a cleavable linker in ADC synthesis. These targeted therapies aim to combat cancer specifically. The ingenious design of the linker ensures stability in the bloodstream, yet precise cleavage in the tumor microenvironment, releasing cytotoxic drugs. This specificity not only minimizes harm to healthy cells but also maximizes the therapeutic impact on cancerous cells.

Drug Delivery Systems: Delving into the domain of drug delivery, Fmoc-Val-Cit-PAB-PNP facilitates the development of intricate systems that release therapeutic agents in response to specific triggers. This innovative linker technology empowers engineered compounds to deliver drugs with surgical precision, elevating treatment outcomes for conditions like inflammatory diseases and chronic infections.

Bioconjugation Techniques: As a fundamental component in bioconjugation methodologies, Fmoc-Val-Cit-PAB-PNP facilitates the conjugation of various molecules to peptides and proteins with unparalleled specificity. This capability proves invaluable for constructing peptide libraries, probing intricate protein interactions, and crafting diagnostic tools.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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