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Mal-amido-PEG9-Val-Ala-PAB-SG3200 is a cleavable ADC linker conjugate used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01740 | -- | $-- | Inquiry |
Mal-amido-PEG9-Val-Ala-PAB-SG3200, a multifunctional linker utilized in drug delivery and bioconjugation strategies, showcases a diverse range of applications.
Antibody-Drug Conjugates (ADCs): Positioned at the forefront of targeted cancer therapies, Mal-amido-PEG9-Val-Ala-PAB-SG3200 assumes a crucial role in ADC development. Acting as a linker, it bridges a cytotoxic drug to an antibody designed to specifically target cancer cells. This precise delivery mechanism amplifies the therapeutic index by concentrating the drug at the tumor site while concurrently minimizing systemic toxicity.
Protein-PEGylation: Within the realm of protein modification, this compound serves as a cornerstone for PEGylating proteins to augment their pharmacokinetic attributes, encompassing solubility, stability, and half-life extension. By conjugating polyethylene glycol (PEG) chains to therapeutic proteins, it decelerates renal clearance and evades immune recognition, resulting in heightened bioavailability and prolonged therapeutic efficacy of protein-based medications.
Cell-Penetrating Peptides: Mal-amido-PEG9-Val-Ala-PAB-SG3200 facilitates the transport of biologically active agents across cellular barriers. By tethering bioactive components to cell-penetrating peptides, it magnifies cellular uptake and enables efficient delivery into intracellular domains.
Bioconjugation Techniques: Embracing the realm of bioconjugation, this versatile compound intertwines diverse biomolecules – nucleic acids, proteins, or small molecules – in a controlled, precise manner. Its utilization in forging stable linkages plays a pivotal role in crafting diagnostic tools, biosensors, and therapeutic interventions.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
