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Mal-amido-PEG8-val-gly-PAB-OH is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01097 | -- | $-- | Inquiry |
Mal-amido-PEG8-val-gly-PAB-OH is a bifunctional linker used primarily in the field of bioconjugation. Here are some key applications of Mal-amido-PEG8-val-gly-PAB-OH:
Antibody-Drug Conjugates (ADCs): This compound is widely used in the synthesis of antibody-drug conjugates, which are designed for targeted cancer therapy. Mal-amido-PEG8-val-gly-PAB-OH serves as a linker to attach cytotoxic drugs to antibodies, facilitating the delivery of the drug specifically to cancer cells. This targeted approach minimizes off-target effects and enhances the therapeutic index.
Protein Labeling: Mal-amido-PEG8-val-gly-PAB-OH can be used for the covalent modification of proteins, allowing researchers to attach various probes for detection or purification purposes. Its PEG spacer provides enhanced solubility and reduced steric hindrance, ensuring efficient conjugation. This is particularly useful in proteomics and diagnostics for tracking and analyzing proteins.
Pharmacokinetics Studies: The PEG component of Mal-amido-PEG8-val-gly-PAB-OH can help improve the pharmacokinetic properties of small molecules and peptides. By enhancing the solubility and stability of the conjugates, it can prolong the circulation time of therapeutic compounds. Researchers use this advantage to develop drug formulations with better bioavailability and reduced immunogenicity.
Nanoparticle Functionalization: This compound is also employed in the functionalization of nanoparticles designed for drug delivery systems. Mal-amido-PEG8-val-gly-PAB-OH can be used to attach targeting ligands or therapeutic agents to the surface of nanoparticles. This application enhances the specificity and efficiency of nanoparticle-based treatments, especially in oncology and precision medicine.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
