Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate - CAS 2112738-60-8

Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate - CAS 2112738-60-8 Catalog number: BADC-01543

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Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate is a linker widely used in antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate
CAS
2112738-60-8
Catalog Number
BADC-01543
Molecular Formula
C37H54N4O19
Molecular Weight
858.84
Purity
95%
Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate

Ordering Information

Catalog Number Size Price Quantity
BADC-01543 -- $-- Inquiry
Description
Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate is a linker widely used in antibody-drug conjugates (ADCs).
Synonyms
N-Mal-N-bis(PEG4-NHS ester); Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl-[3-(2,5-dioxopyrrol-1-yl)propanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(=O)CCN3C(=O)C=CC3=O
InChI
InChI=1S/C37H54N4O19/c42-29(7-10-39-30(43)1-2-31(39)44)38(11-15-53-19-23-57-27-25-55-21-17-51-13-8-36(49)59-40-32(45)3-4-33(40)46)12-16-54-20-24-58-28-26-56-22-18-52-14-9-37(50)60-41-34(47)5-6-35(41)48/h1-2H,3-28H2
InChIKey
OMOYDOIENLEOQM-UHFFFAOYSA-N
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pictograms
Harmful
Signal Word
Warning

Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-13,1-dioate, a versatile chemical reagent, widely employed in bioconjugation and molecular biology, manifests four key applications with elevated perplexity and burstiness:

Protein Labeling: In the intricate realm of bioconjugation, this compound interacts with primary amines on proteins to establish stable amide bonds, facilitating the attachment of fluorescent dyes, biotin, or other molecular tags. This process enables the visualization and tracking of proteins in diverse biological and biochemical assays, shedding light on the complex dynamics of proteins with meticulous precision.

Drug Delivery Systems: Within the expansive domain of drug delivery exploration, this compound assumes a pivotal role in conjugating therapeutic agents to carrier molecules like polyethylene glycol (PEG), ensuring controlled release and heightened bioavailability of drugs to specific tissues. This strategic approach is paramount for advancing precise and targeted drug delivery systems, revolutionizing therapeutic interventions with advanced levels of precision.

Antibody-Drug Conjugates: Serving as an indispensable component for synthesizing antibody-drug conjugates (ADCs), this reagent facilitates the precise linkage of cytotoxic drugs to monoclonal antibodies. By directing the drug explicitly to cancer cells while minimizing off-target effects, this approach unveils a promising avenue for potent cancer therapies.

Surface Coating: In sophisticated surface modification techniques, this compound empowers the immobilization of biomolecules onto an array of surfaces, including microarrays and biosensors, through covalent binding. This intricate process enhances the stability and functionality of the immobilized molecules, laying the groundwork for cutting-edge diagnostic devices and biosensor technologies, thereby expanding the boundaries of bioanalytical applications to uncharted territories.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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