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Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-1,31-dioate is a linker widely used in antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01543 | -- | $-- |
Bis(2,5-dioxopyrrolidin-1-yl) 16-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontane-13,1-dioate, a versatile chemical reagent, widely employed in bioconjugation and molecular biology, manifests four key applications with elevated perplexity and burstiness:
Protein Labeling: In the intricate realm of bioconjugation, this compound interacts with primary amines on proteins to establish stable amide bonds, facilitating the attachment of fluorescent dyes, biotin, or other molecular tags. This process enables the visualization and tracking of proteins in diverse biological and biochemical assays, shedding light on the complex dynamics of proteins with meticulous precision.
Drug Delivery Systems: Within the expansive domain of drug delivery exploration, this compound assumes a pivotal role in conjugating therapeutic agents to carrier molecules like polyethylene glycol (PEG), ensuring controlled release and heightened bioavailability of drugs to specific tissues. This strategic approach is paramount for advancing precise and targeted drug delivery systems, revolutionizing therapeutic interventions with advanced levels of precision.
Antibody-Drug Conjugates: Serving as an indispensable component for synthesizing antibody-drug conjugates (ADCs), this reagent facilitates the precise linkage of cytotoxic drugs to monoclonal antibodies. By directing the drug explicitly to cancer cells while minimizing off-target effects, this approach unveils a promising avenue for potent cancer therapies.
Surface Coating: In sophisticated surface modification techniques, this compound empowers the immobilization of biomolecules onto an array of surfaces, including microarrays and biosensors, through covalent binding. This intricate process enhances the stability and functionality of the immobilized molecules, laying the groundwork for cutting-edge diagnostic devices and biosensor technologies, thereby expanding the boundaries of bioanalytical applications to uncharted territories.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
