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CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00621 | -- | $-- |
CL2A is a versatile compound used in various scientific and industrial applications. Here are some key applications of CL2A:
Fluorescence Imaging: CL2A is widely used in fluorescence imaging techniques due to its strong fluorescent properties. Scientists employ CL2A as a fluorescent probe to label and visualize cellular structures, proteins, and other biomolecules. This application is crucial for live cell imaging and studying molecular dynamics in real-time.
Bioconjugation: CL2A is effective in bioconjugation processes, where it is used to attach fluorescent labels to antibodies, peptides, and nucleic acids. Through this process, researchers can track and quantify these biomolecules in complex biological systems. This is essential for diagnostic assays, molecular tracking, and therapeutic monitoring.
Environmental Monitoring: Due to its sensitivity and specificity, CL2A is used in environmental monitoring to detect trace amounts of pollutants and toxins. By labeling environmental samples with CL2A, analysts can identify and quantify the presence of hazardous substances. This helps in assessing environmental health and ensuring compliance with regulatory standards.
Pharmaceutical Development: In pharmaceutical development, CL2A is utilized for high-throughput screening assays to identify potential drug candidates. By incorporating CL2A into these assays, researchers can rapidly assess the activity and interaction of numerous compounds. This accelerates the drug discovery process and enhances the efficiency of pharmaceutical research.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
