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| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01259 | -- | $-- | Inquiry |
Endo-BCN-PEG4-Val-Cit-PAB-MMAE, a versatile linker-drug, plays a pivotal role in targeted cancer therapies, particularly in the development of antibody-drug conjugates (ADCs). Here are four key applications of this compound:
Targeted Drug Delivery: Endo-BCN-PEG4-Val-Cit-PAB-MMAE serves as a sophisticated tool for delivering cytotoxic agents directly to cancer cells in a precise manner. By conjugating with antibodies that target specific cancer cell markers, this compound orchestrates the selective destruction of cancer cells while safeguarding healthy tissues. This innovative approach not only boosts treatment effectiveness but also diminishes the adverse effects commonly associated with traditional chemotherapy regimens.
Tumor Microenvironment Studies: Delving deeper into the intricate dynamics of the tumor microenvironment, researchers utilize this linker-drug to investigate how drugs behave and interact within this specialized milieu. By monitoring the controlled release and activation of MMAE in response to tumor-specific conditions, valuable insights are gleaned regarding the mechanism of action and pharmacodynamics of ADCs. Such insights prove instrumental in refining ADC designs and enhancing therapeutic outcomes.
Preclinical Evaluation of ADCs: Widely employed in preclinical investigations, Endo-BCN-PEG4-Val-Cit-PAB-MMAE plays a crucial role in assessing the safety, efficacy, and pharmacokinetics of newly developed ADCs. These meticulous evaluations encompass both in vitro and in vivo studies to ascertain the stability, target specificity, and cytotoxic potency of the conjugates.
Combination Therapy Research: In the realm of combination therapy research, Endo-BCN-PEG4-Val-Cit-PAB-MMAE emerges as a key player in exploring synergistic effects with other cancer treatments. Pairing this ADC with complementary therapeutic agents, like immune checkpoint inhibitors or conventional chemotherapy strategies, holds the promise of boosting overall anticancer activity.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
