Fmoc-D-Val-D-Cit-PAB - CAS 1350456-69-7

Fmoc-D-Val-D-Cit-PAB - CAS 1350456-69-7 Catalog number: BADC-00931

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Category
ADCs Linker
Product Name
Fmoc-D-Val-D-Cit-PAB
CAS
1350456-69-7
Catalog Number
BADC-00931
Molecular Formula
C33H39N5O6
Molecular Weight
601.69
Purity
>98.0%

Ordering Information

Catalog Number Size Price Quantity
BADC-00931 -- $-- Inquiry

Related Molecules

Synonyms
9H-Fluoren-9-ylmethyl N-[(2R)-1-[[(2R)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
InChI
InChI=1S/C33H39N5O6/c1-20(2)29(38-33(43)44-19-27-25-10-5-3-8-23(25)24-9-4-6-11-26(24)27)31(41)37-28(12-7-17-35-32(34)42)30(40)36-22-15-13-21(18-39)14-16-22/h3-6,8-11,13-16,20,27-29,39H,7,12,17-19H2,1-2H3,(H,36,40)(H,37,41)(H,38,43)(H3,34,35,42)/t28-,29-/m1/s1
InChIKey
DALMAZHDNFCDRP-FQLXRVMXSA-N
Solubility
10 mm in DMSO
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
-20°C (International: -20°C)
Storage
Store at -5°C,keep in dry and avoid sunlight.

Fmoc-D-Val-D-Cit-PAB, a synthetic peptide with diverse research and therapeutic uses, is a key component in various applications. Here are four key applications of Fmoc-D-Val-D-Cit-PAB:

Peptide Synthesis: Serving as a critical element in solid-phase peptide synthesis (SPPS), Fmoc-D-Val-D-Cit-PAB facilitates the efficient construction of intricate peptides and proteins. Its incorporation of D-amino acids can bolster peptide stability and biological activity, essential for tailoring custom peptides for both research and therapeutic initiatives.

Drug Delivery: Playing a pivotal role in prodrug development, Fmoc-D-Val-D-Cit-PAB acts as a cleavable linker for precise drug delivery mechanisms. Upon reaching the target site, the peptide linker undergoes enzymatic cleavage, releasing the active drug. This targeted delivery system aims to minimize side effects and optimize therapeutic efficacy.

Bioconjugation: Instrumental in bioconjugation processes, Fmoc-D-Val-D-Cit-PAB acts as a pivotal linker connecting peptides to various molecules such as drugs, fluorescent dyes, or nanoparticles. This linkage facilitates the creation of multifunctional biomolecules crucial for diagnostic and therapeutic applications. These conjugates play a crucial role in targeted imaging and therapeutic strategies, enhancing the realm of medical research.

Protease Studies: In the realm of protease activity research, Fmoc-D-Val-D-Cit-PAB finds its place by being incorporated into peptide substrates designed for specific protease cleavage. By monitoring the cleavage of these substrates, researchers gain insights into protease functions and their involvement in diverse biological processes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Fmoc-D-Val-D-Cit-PAB
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