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mPEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00890 | -- | $-- | Inquiry |
mPEG4-bromide is a versatile chemical compound widely used in biochemical research and pharmaceutical applications. Here are some key applications of mPEG4-bromide:
Protein Modification: mPEG4-bromide is commonly used to modify proteins through a process called PEGylation, which involves attaching polyethylene glycol (PEG) chains to proteins. This modification enhances protein stability, solubility, and circulation time in the body, making it valuable for therapeutic protein development. PEGylated proteins exhibit reduced immunogenicity and improved pharmacokinetics, essential for effective drug delivery.
Drug Delivery Systems: In pharmaceutical applications, mPEG4-bromide is employed to create novel drug delivery systems. By conjugating with drug molecules, mPEG4-bromide enhances the solubility and bioavailability of hydrophobic drugs. This approach facilitates the design of targeted therapies with controlled release profiles, optimizing drug efficacy and patient outcomes.
Surface Coating: mPEG4-bromide is utilized in the development of biocompatible surface coatings for medical devices. By coating surfaces with PEG, it reduces protein adsorption and minimizes immune responses, ensuring compatibility with the human body. These properties are crucial for the performance and longevity of implants, catheters, and other medical devices.
Diagnostic Assays: In the field of diagnostics, mPEG4-bromide is used to modify biomolecules for use in various assays and detection systems. It can improve the sensitivity and specificity of diagnostic tests by reducing nonspecific binding and enhancing signal detection. This makes it an invaluable tool in the development of reliable and accurate diagnostic platforms.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
