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(S)-2,5-Dioxopyrrolidin-1-yl 4-(methyldisulfanyl)pentanoate is a linker widely used in antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01538 | -- | $-- |
(S)-2,5-Dioxopyrrolidin-1-yl 4-(methyldisulfanyl)pentanoate, a versatile chemical compound with wide-ranging applications in biochemical and pharmaceutical research. Here are four key applications presented with high perplexity and burstiness:
Protein Labeling and Modification: Unlocking the potential for protein manipulation, this compound plays a pivotal role in introducing disulfide bonds into proteins, thus facilitating protein labeling and enabling detailed structural studies. By interacting with thiol groups on proteins, it fosters the creation of durable covalent bonds for labeling purposes. This essential function is critical for exploring the intricacies of protein-protein interactions and delving into the stability of protein folds.
Drug Delivery Systems: Embarking on the realm of drug delivery innovation, (S)-2,5-Dioxopyrrolidin-1-yl 4-(methyldisulfanyl)pentanoate emerges as a key player in the design of prodrugs and sophisticated drug delivery systems. By incorporating this compound into drug formulations, the doors open to crafting controlled-release systems that activate under precise physiological conditions. This strategic approach ensures targeted delivery, minimizing systemic side effects, and amplifying therapeutic effectiveness.
Bioconjugation: In the realm of bioconjugation mastery, this compound shines as an indispensable tool for seamlessly linking biomolecules like peptides, proteins, and antibodies to a diverse array of substrates. Its exceptional reactivity with sulfhydryl groups serves as the cornerstone for creating bioconjugates that retain the inherent activity and specificity of the original biomolecules. These conjugates stand as valuable assets in the realm of diagnostic assay development and therapeutic agent advancement.
Redox Biology Research: Delving into the fascinating domain of redox biology, (S)-2,5-Dioxopyrrolidin-1-yl 4-(methyldisulfanyl)pentanoate emerges as an instrumental tool for exploring the intricacies of disulfide bond formation and reduction. By facilitating redox reactions, it opens up avenues for investigating the complex interplay between oxidative and reductive processes within biological systems. This crucial application stands at the forefront of unraveling the mysteries of cellular redox homeostasis and shedding light on the pivotal role of oxidative stress in the realm of diseases.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
