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Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01024 | -- | $-- |
Amino-PEG4-acetic acid, a versatile chemical with diverse applications in bioscience, plays a crucial role in various cutting-edge fields. Here are four key applications showcased with high perplexity and burstiness:
Bioconjugation: A pivotal application of Amino-PEG4-acetic acid lies in bioconjugation reactions, where it acts as a bridge linking biomolecules such as peptides, proteins, and antibodies to different molecules or surfaces. The inclusion of its polyethylene glycol (PEG) spacer enhances flexibility and diminishes steric hindrance, thus elevating the stability and activity of the resultant conjugated biomolecules. This technique is indispensable in the development of targeted therapeutics and diagnostic tools, enabling precise and efficient molecular connections.
Drug Delivery Systems: Amino-PEG4-acetic acid is a cornerstone in the realm of drug delivery systems, serving as a crucial linker for attaching therapeutic agents to carriers like nanoparticles or liposomes. The presence of the PEG moiety contributes to enhancing the solubility and biocompatibility of the drug carriers, ultimately leading to prolonged circulation time and effective drug delivery to targeted tissues. This function stands as a critical factor in enhancing the efficacy and minimizing potential side effects of pharmaceuticals.
Surface Modification: Leveraging its prowess, Amino-PEG4-acetic acid finds extensive utility in the realm of surface modification, particularly in enhancing the biocompatibility and reducing fouling of medical devices and biosensors. The PEG chain effectively mitigates protein adsorption and cellular adhesion, thereby elevating device performance and extending its longevity. These tailored modifications are especially essential in the development of implants, catheters, and diagnostic sensors.
Protein Purification: Another critical application of Amino-PEG4-acetic acid is in affinity purification techniques aimed at isolating specific proteins from complex mixtures. By binding to a target protein or ligand, it facilitates the purification process through affinity chromatography, ensuring high-purity end products suitable for various applications, be it in research, therapy, or industrial settings. This application stands pivotal in ensuring the production of immaculate proteins, propelling advancements in diverse fields requiring purified biomolecules.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
