Azido-PEG1-Val-Cit-OH

Azido-PEG1-Val-Cit-OH Catalog number: BADC-01220

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Category
ADCs Linker
Product Name
Azido-PEG1-Val-Cit-OH
Catalog Number
BADC-01220
Molecular Formula
C16H29N7O6
Molecular Weight
415.44
Purity
≥95%

Ordering Information

Catalog Number Size Price Quantity
BADC-01220 -- $-- Inquiry
Solubility
10 mm in DMSO
Shelf Life
-20°C 3 years powder; -80°C 2 years in solvent
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C, keep in dry and avoid sunlight.

Azido-PEG1-Val-Cit-OH, a versatile linker compound utilized in bioconjugation and drug delivery systems, finds diverse applications. Here are four key applications:

Antibody-Drug Conjugates (ADCs): Employing Azido-PEG1-Val-Cit-OH as a pivotal linker in ADC synthesis, researchers craft targeted therapies for cancer by merging antibodies with cytotoxic drugs. This sophisticated linker ensures steadfast attachment of the drug to the antibody, enabling controlled release upon binding to the cancer cell target.

Proteomics: Within the realm of proteomics research, Azido-PEG1-Val-Cit-OH serves as a valuable tool for labeling proteins with fluorescent tags or other probes. This labeling strategy enables scrutiny of protein interactions, modifications, and functions within intricate biological systems. The cleavable nature of the linker facilitates the isolation of labeled proteins, paving the way for in-depth analysis and deeper insights into cellular processes.

Site-Specific Bioconjugation: Azido-PEG1-Val-Cit-OH facilitates precise bioconjugation through “click chemistry,” a bio-orthogonal reaction enabling targeted attachment of therapeutic agents, imaging probes, or functional molecules to specific biomolecules. This unparalleled specificity is essential for the development of precision-targeted therapies and advanced diagnostic tools.

Drug Delivery Systems: Fostering innovation in drug delivery systems, Azido-PEG1-Val-Cit-OH plays a pivotal role in designing sophisticated nanoparticles and polymer-drug conjugates. This versatile linker ensures stable drug incorporation within the delivery vehicle, enabling controlled release in response to specific cellular cues. By enhancing drug solubility, bioavailability, and targeted delivery to diseased tissues, this approach revolutionizes drug delivery, promising optimized therapeutic outcomes.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: SPP | Azido-PEG1-Val-Cit-OH
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