Boc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide. It is also a protease-cleavable linker for antibody-drug conjugates (ADCs).
Catalog Number | Size | Price | Quantity |
---|---|---|---|
BADC-00622 | 250 mg | $198 |
Boc-Gly-Gly-Phe-Gly-OH, also known as N-(tert-Butoxycarbonyl)-glycyl-glycyl-L-phenylalanylglycine, is a peptide featuring notable versatility in research and pharmaceutical applications. First and foremost, it is extensively employed in the field of proteomics for protein structure and function analysis. The peptide serves as a valuable standard or control in mass spectrometry and chromatography, allowing researchers to better understand protein interactions and enzymatic activities critical to cellular processes. By offering insight into the conformational properties of proteins in different environments, Boc-Gly-Gly-Phe-Gly-OH significantly aids in elucidating the mechanisms underlying disease pathogenesis, especially in neurodegenerative and metabolic disorders.
Another significant application of Boc-Gly-Gly-Phe-Gly-OH is in the development of novel therapeutic agents. The peptide can be included in drug design and testing processes to evaluate pharmacokinetics, stability, and bioavailability of new compounds. Studying the interactions of this peptide with potential drug molecules enables scientists to identify and optimize lead compounds with better efficacy and reduced side effects. Moreover, the peptide’s structural properties make it an ideal candidate for mimicking certain endogenous peptides, thus paving the way for innovative treatments for diseases such as cancer, diabetes, and inflammatory disorders.
In the realm of synthetic biology, Boc-Gly-Gly-Phe-Gly-OH plays a crucial role in the design and synthesis of artificial proteins and peptides. As a building block, it is used to construct larger peptide chains that imitate natural biological functions, aiding in the creation of biomaterials with specific properties tailored for medical applications. For instance, these engineered peptides can be used in tissue engineering, wound healing, and the development of novel scaffolds for regenerative medicine. The ability to precisely control the peptide sequences enhances the understanding of protein engineering and can potentially lead to breakthrough innovations in biomedicine.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.