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m-PEG12-amine is a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01648 | -- | $-- | Inquiry |
m-PEG12-amine, a functionalized polyethylene glycol (PEG) derivative, finds extensive use in diverse biochemical and pharmaceutical applications. Here are four key applications of m-PEG12-amine:
Drug Delivery Systems: An indispensable player in the realm of drug delivery systems, m-PEG12-amine plays a pivotal role in enhancing the solubility and stability of therapeutic agents. By grafting PEG chains onto drugs, their pharmacokinetic properties are bolstered, resulting in prolonged circulation in the bloodstream. This optimization facilitates controlled and sustained drug release, thereby amplifying therapeutic efficacy to new heights.
Protein Conjugation: In the intricate landscape of protein biochemistry, m-PEG12-amine emerges as a prized reagent for PEGylation, a transformative process that enhances proteins’ stability and diminishes immunogenicity. Through the strategic conjugation of PEG to therapeutic proteins or enzymes, researchers elevate their solubility and extend their in vivo half-lives.
Surface Modification: A linchpin in biomaterial surface modification, m-PEG12-amine shines in its ability to curtail non-specific protein adsorption and heighten biocompatibility. By enveloping medical devices or nanoparticles with PEG coatings, a stealth effect is created, shielding them from immune system recognition and clearance.
Diagnostics: Catalyst for innovation in diagnostics, m-PEG12-amine takes center stage in crafting bioconjugates for assays and imaging techniques. By tethering PEG to antibodies, peptides, or other biomolecules, the stability of labeling agents is fortified, preserving their binding properties. This meticulous process results in heightened signal detection and specificity in diagnostic applications like ELISA and magnetic resonance imaging.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
