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2,5-dioxopyrrolidin-1-yl 18-((4-(3,5-dioxohexyl)phenyl)amino)-14,18-dioxo-4,7,10-trioxa-13-azaoctadecan-1-oate is a linker for antibody-drug-conjugation (ADC).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00688 | -- | $-- |
2,5-Dioxopyrrolidin-1-yl 18-((4-(3,5-dioxohexyl)phenyl)amino)-14,18-dioxo-4,7,10-trioxa-13-azaoctadecan-1-oate is predominantly used in drug delivery systems due to its unique chemical structure. The compound’s ability to form stable, non-covalent interactions with a variety of drugs makes it ideal for targeted drug delivery. This capability ensures that the drug reaches the desired site of action within the body, minimizing side effects and enhancing therapeutic efficacy. By facilitating controlled release, it helps in maintaining optimal drug concentration in the bloodstream, which is crucial for the treatment of chronic diseases.
Another key application of this compound is in protein and peptide conjugation. The presence of multiple reactive sites allows it to easily form covalent bonds with peptides, thereby increasing their stability and solubility. This is particularly beneficial in the development of biopharmaceuticals, where stability and controlled activity are of utmost importance. Peptide conjugates can be designed to have prolonged circulation time in the bloodstream, enhancing their therapeutic potential without compromising activity.
In the field of diagnostics, this compound finds application in the development of advanced imaging agents. Its structural properties enable it to serve as a linker for attaching contrast agents to specific antibodies or targeting molecules. This targeted approach improves the accuracy and sensitivity of diagnostic imaging techniques, such as MRI and CT scans. By providing high-contrast images, it aids in the early detection and accurate diagnosis of various diseases, including cancers and cardiovascular conditions. The specificity of targeting significantly reduces the background noise, making the diagnostic process more reliable.
Additionally, 2,5-Dioxopyrrolidin-1-yl 18-((4-(3,5-dioxohexyl)phenyl)amino)-14,18-dioxo-4,7,10-trioxa-13-azaoctadecan-1-oate is widely used in materials science for the development of functionalized polymers. The compound’s reactive sites facilitate covalent attachment to polymer backbones, resulting in functionalized polymers with improved properties such as increased strength, flexibility, and resistance to environmental factors. These advanced materials find applications in various industries, including biomedical devices, coatings, and packaging. The ability to tailor the physical and chemical properties of these polymers opens new avenues for innovation in material design and application.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
