2, 5-Dioxopyrrolidin-1-yl 4-((2-((2-(2-(4-(2, 6-dioxo-1, 3-dipropyl-2, 3, 6, 9-tetrahydro-1H-purin-8-yl)phenoxy)acetamido)ethyl)amino)ethyl)disulfanyl)-4-oxobutanoate is a linker for antibody-drug-conjugation (ADC).
Catalog Number | Size | Price | Quantity | ||
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BADC-00528 | -- | $-- | Inquiry |
One of the key applications of 2,5-Dioxopyrrolidin-1-yl 4-((2-((2-(2-(4-(2,6-Dioxo-1,3-Dipropyl-2,3,6,9-Tetrahydro-1H-Purin-8-Yl)phenoxy)acetamido)ethyl)amino)ethyl)disulfanyl)-4-Oxobutanoate is in drug development and pharmaceutical research. This compound can serve as a scaffold or intermediate in the synthesis of drugs targeting various biological pathways. The purine moiety in its structure is particularly significant because purine derivatives are well-known for their bioactive properties, being essential constituents in compounds that can interact with nucleic acids and proteins. This makes the compound valuable for creating new therapies aimed at treating diseases such as cancer, viral infections, and inflammatory conditions.
Another important application is in biochemical research, specifically in the study of enzyme mechanisms and protein interactions. The presence of both a disulfide bond and an oxobutanoate group in the compound makes it a useful probe for investigating redox reactions and thiol-disulfide exchange processes in biological systems. Researchers can use it to label, track, and understand the behavior of proteins and other biomolecules under various conditions, shedding light on intricate cellular processes and potentially leading to the identification of new therapeutic targets.
The compound also finds application in the development of diagnostic tools and assays. Due to its complex structure, bearing multiple functional groups, it can be engineered to act as a reporter molecule or a binding agent in various diagnostic platforms. For instance, it can be used in assays designed to detect specific biomolecules or pathological changes in biological samples, contributing to the early and accurate diagnosis of diseases. Its ability to bind selectively and specifically to certain targets enhances the sensitivity and specificity of diagnostic tests.
Lastly, 2,5-Dioxopyrrolidin-1-yl 4-((2-((2-(2-(4-(2,6-Dioxo-1,3-Dipropyl-2,3,6,9-Tetrahydro-1H-Purin-8-Yl)phenoxy)acetamido)ethyl)amino)ethyl)disulfanyl)-4-Oxobutanoate is utilized in molecular biology and genetic engineering. The compound’s intricate structure allows it to be incorporated into probes or primers used in techniques like PCR (Polymerase Chain Reaction) and DNA sequencing. These applications are critical for genetic analysis and manipulation, helping researchers to understand genetic codes, identify mutations, and engineer genetic modifications. This contributes significantly to advancements in fields such as agriculture, biotechnology, and personalized medicine.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.