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2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2-(cyclooct-2-ynyloxy)acetamido)ethoxy)ethoxy)propanoate is a pharmaceutical compound widely used in the biomedical field. Its powerful medicinal properties are effective against drug-resistant strains, especially in overcoming Gram-positive infections.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00425 | -- | $-- |
The first key application of 2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2-(cyclooct-2-ynyloxy)acetamido)ethoxy)ethoxy)propanoate is in the field of bioconjugation. This compound can be used to create a stable linkage between various bio-molecules such as proteins, antibodies, peptides, and other biological entities. The reactive N-hydroxysuccinimide (NHS) ester group is a critical functional element allowing it to efficiently conjugate with primary amines found in proteins and peptides. This makes it a versatile tool in generating bioconjugates for use in diagnostics, therapeutics, and research applications. Through successful bioconjugation, scientists can develop more effective enzyme-linked immunosorbent assays (ELISAs), antibody-drug conjugates (ADCs), and multi-functional biomolecules for targeted drug delivery and precise diagnostic tools.
Another significant application of this compound is in drug delivery systems. The presence of the cyclooctynyl moiety in its structure allows it to be used in click chemistry reactions, specifically strain-promoted alkyne-azide cycloaddition (SPAAC). This reaction enables rapid, biocompatible covalent bonding under mild conditions, making it suitable for use in vivo. By utilizing the click chemistry approach, 2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2-(cyclooct-2-ynyloxy)acetamido)ethoxy)ethoxy)propanoate can be used to develop advanced drug delivery vehicles. These vehicles can be functionalized with targeting ligands or therapeutic agents, providing controlled and site-specific release of drugs. This leads to enhanced efficacy and reduced side effects, improving the overall outcomes in treatments of diseases like cancer, infectious diseases, and chronic conditions.
The third application of this compound lies in the development of advanced biomaterials. With the increasing need for materials that can mimic the properties of natural tissues, 2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2-(cyclooct-2-ynyloxy)acetamido)ethoxy)ethoxy)propanoate can be employed in the synthesis of functionalized polymers and hydrogels. These materials can be engineered to present specific biological signals, enhancing cell adhesion, proliferation, and differentiation. In tissue engineering and regenerative medicine, this enables the creation of scaffolds that support the growth and integration of new tissues, facilitating the repair and regeneration of damaged tissues. The ability to conjugate this compound with different bioactive molecules allows for the customization of biomaterials for various applications, including wound healing, artificial organs, and biomedical implants.
Lastly, this compound has applications in bioorthogonal chemistry, which involves chemical reactions that can occur inside living organisms without interfering with native biochemical processes. This unique property makes 2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2-(cyclooct-2-ynyloxy)acetamido)ethoxy)ethoxy)propanoate valuable for in vivo labeling and imaging. By tagging biomolecules with this compound, researchers can track and visualize cellular processes in real-time, providing insights into cellular signaling, protein interactions, and metabolic pathways. The high specificity and biocompatibility of bioorthogonal reactions ensure minimal disruption to the organism while yielding accurate and dynamic biological data. This application is particularly valuable in the fields of developmental biology, neuroscience, and cancer research, where understanding intricate biological systems is crucial.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
