DBCO-amine - CAS 1255942-06-3

DBCO-amine - CAS 1255942-06-3 Catalog number: BADC-00908

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Category
ADCs Linker
Product Name
DBCO-amine
CAS
1255942-06-3
Catalog Number
BADC-00908
Molecular Formula
C18H16N2O
Molecular Weight
276.33
DBCO-amine

Ordering Information

Catalog Number Size Price Quantity
BADC-00908 -- $--
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Synonyms
Azadibenzocyclooctyne-amine
Canonical SMILES
C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCN
InChI
InChI=1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2
InChIKey
OCCYFTDHSHTFER-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Melting Point
86-96 °C
LogP
3.04710
PSA
46.33000
Appearance
Slightly yellow to slightly crystalline
Purity
95 %
Shipping
Room temperature, or blue ice upon request.
Storage
Store at -20 °C
Signal Word
Warning

DBCO-amine, a highly versatile chemical widely utilized in bioconjugation and molecular biology, offers a myriad of applications.

Bioconjugation: Known for facilitating the formation of stable covalent bonds between biomolecules, DBCO-amine employs its strain-promoted azide-alkyne cycloaddition (SPAAC) reaction to intricately attach to azide-modified molecules without relying on copper catalysts. This unique feature renders it an indispensable tool for labeling proteins, nucleic acids, and other biomolecules across various research and diagnostic realms, showcasing its versatility and efficiency.

Drug Delivery: In the realm of drug delivery, DBCO-amine plays a pivotal role in conjugating therapeutic agents to targeting moieties like antibodies or peptides, thereby enhancing the precision and effectiveness of drug delivery systems. This strategic attachment ensures the precise delivery of therapeutic compounds to their intended cellular targets, ultimately enhancing the therapeutic index and minimizing off-target effects.

Bioorthogonal Chemistry: As a cornerstone reagent in bioorthogonal chemistry, DBCO-amine enables researchers to conduct chemical reactions within living organisms without disrupting native biochemical processes. This unique property is harnessed to produce labeled biomolecules for in vivo imaging studies, providing real-time insights into biological processes. Such cutting-edge applications are essential for advancing our comprehension of intricate biological systems and disease pathologies, offering a window into the inner workings of living organisms.

Surface Modification: Utilized in the surface modification of nanoparticles and biosensors, DBCO-amine facilitates the attachment of functional biomolecules to improve performance. Through the covalent linking of biomolecules to surfaces, researchers can enhance the sensitivity and specificity of diagnostic devices or innovate novel materials for biomedical applications. This innovative approach propels the development of sophisticated detection systems and therapeutic platforms, setting new standards for bioengineering advancements.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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