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Amino-PEG4-bis-PEG3-N3 is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01212 | -- | $-- |
Amino-PEG4-bis-PEG3-N3, a polyethylene glycol (PEG) derivative, is an important compound in bioconjugation chemistry and biomedical research. One key application of this compound is in drug delivery systems. Its structure allows it to enhance the solubility and stability of hydrophobic drugs, increasing their bioavailability and circulation time in the body. This makes it highly valuable for the development of novel therapeutics, particularly in targeting specific cells or tissues. By linking drugs to the Amino-PEG4-bis-PEG3-N3, researchers can achieve more controlled and efficient drug release profiles, improving therapeutic outcomes.
Another significant application of Amino-PEG4-bis-PEG3-N3 is in the realm of diagnostics. The compound can be used to attach contrast agents or radioactive markers to biomolecules, enhancing the imaging capabilities of diagnostic techniques such as MRI, PET, and CT scans. This enables more precise visualization of biological processes and disease states within the body. Furthermore, the biocompatibility and low immunogenicity of PEG make it an ideal choice for in vivo applications, ensuring that the diagnostic agents do not trigger adverse immune responses in patients.
Amino-PEG4-bis-PEG3-N3 is also widely used in the development of biomaterials and tissue engineering. Its ability to link various bioactive molecules facilitates the creation of customized surfaces and scaffolds that can promote cell adhesion, growth, and differentiation. This is particularly useful in the fabrication of artificial organs and tissues, where the integration of specific signaling molecules can significantly enhance the functionality and biocompatibility of the engineered constructs. The versatility of this PEG derivative makes it indispensable in the advancement of regenerative medicine and therapeutic biomaterials.
Lastly, Amino-PEG4-bis-PEG3-N3 finds application in the field of molecular biology and protein engineering. It is often used to modify proteins and peptides in order to improve their solubility, stability, and functional properties. This can be crucial for the production of therapeutic proteins and enzymes, where maintaining high activity and reducing aggregation are essential for efficacy. Additionally, functionalizing proteins with PEG can extend their half-life in circulation, which is highly beneficial for therapeutic applications. This PEG derivative thus plays a vital role in enhancing the performance and delivery of protein-based therapies.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
