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Azido-PEG5-CH2COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-01076 | -- | $-- |
Azido-PEG5-CH2COOH, a versatile compound prevalent in bioconjugation and click chemistry applications, offers a plethora of uses. Here are four key applications presented with high perplexity and burstiness:
Bioconjugation: Positioned at the core of bioconjugation, Azido-PEG5-CH2COOH acts as a pivotal link for affixing azido groups to a myriad of biomolecules, ranging from proteins to peptides. This connection serves as a gateway to conjugating these molecules with an eclectic array of probes, tags, and other functionalities through the intricate mechanism of click chemistry. The resulting biosensors, drug delivery systems, and diagnostic tools play an indispensable role in the tapestry of biotechnology.
Drug Delivery: Within the sphere of drug delivery systems, Azido-PEG5-CH2COOH assumes a crucial role in refining the surfaces of nanoparticles, liposomes, and other carriers to bolster their stability and biocompatibility. Leveraging the stealth properties conferred by the PEG moiety to prolong circulation time in the bloodstream and harnessing the azide group for subsequent functionalization with targeting moieties or therapeutic agents via click chemistry, this compound serves as a cornerstone in advancing drug delivery mechanisms.
Surface Functionalization: Embracing Azido-PEG5-CH2COOH for surface functionalization of biomaterials like polymers, hydrogels, and medical devices unlocks a realm of possibilities. The inclusion of the azide group facilitates the attachment of a diverse array of molecules, encompassing antifouling agents, cell-adhesion peptides, and growth factors, culminating in the creation of tailored surfaces. This capability proves particularly invaluable in the realm of cutting-edge medical implants and tissue engineering scaffolds.
Chemical Biology: Within the domain of chemical biology, Azido-PEG5-CH2COOH emerges as a pivotal component for delving into biological processes and interactions at the molecular level. By tethering azido groups to specific biomolecules, researchers gain the power to monitor, visualize, and manipulate these entities within living cells utilizing bio-orthogonal click chemistry reactions. This technique facilitates precise labeling and imaging of cellular components, enabling a profound exploration of dynamic biological pathways.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
