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Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01170 | -- | $-- | Inquiry |
Azido-PEG4-t-butyl acetate, a versatile reagent utilized in chemical, pharmaceutical, and biotechnological research, finds diverse applications in the following key areas, presented with a high degree of perplexity and burstiness:
Bioconjugation: In the realm of bioconjugation techniques, Azido-PEG4-t-butyl acetate plays a pivotal role as a linker, connecting biomolecules like proteins or peptides to assorted substrates. The azide group readily engages in click chemistry reactions, giving rise to stable conjugates. This critical application facilitates the labeling, immobilization, and targeted delivery of biomolecules in the realms of research and therapeutic applications, paving the way for innovative advancements in biomolecular interactions and delivery mechanisms.
Drug Delivery: Within the domain of pharmaceutical research, Azido-PEG4-t-butyl acetate emerges as a formidable tool for modifying drug molecules to enhance their solubility and bioavailability. The presence of the PEG component augments the hydrophilicity of hydrophobic drugs, enabling more effective systemic distribution. This transformative modification is instrumental in the development of sophisticated drug delivery systems, optimizing the pharmacokinetic profiles of therapeutic agents and driving forward the landscape of drug delivery technologies.
Surface Modification: Azido-PEG4-t-butyl acetate finds wide-ranging utility in the functionalization of surfaces, spanning nanoparticles, medical devices, and biosensors. By introducing azide groups onto surfaces, researchers unlock the potential for implementing click chemistry in attaching a diverse array of functional moieties. This tailored surface modification enhances the performance and specificity of various biomedical devices, opening up new avenues for fine-tuning surface properties and advancing the frontier of biomedical technologies.
Proteomics: In the multifaceted realm of proteomic studies, Azido-PEG4-t-butyl acetate emerges as a key player in tagging and isolating proteins through bioorthogonal chemistry methodologies. Leveraging the azide group’s selectivity, researchers can tag proteins within complex biological mixes, aiding in their identification and quantification processes. This application proves pivotal in advancing our comprehension of intricate protein interactions, post-translational modifications, and cellular pathways, shedding light on the nuanced mechanisms governing cellular functions and molecular interactions.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
